摘要
Isonitrile group has been identified in many natural products.Due to the broad reactivity of N≡C triple bond,these natural products have valuable pharmaceutical potentials.This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile-containing natural product generation.Based on the strategies utilized,two fundamentally distinctive approaches are discussed.In addition,recent progress in elucidating isonitrile group formation mechanisms is also presented.
基金
This work is supported by the Harry C.Kelly Memorial Fund for U.S.-Japan Scientific Cooperation,through the Office of Global Engagement
the NC Japan Center,at NC State University,Natinnal Institute of Health(GM177588 to W.-c.Cr and Y.G.)
MOST(2019YFA09005000 and 2018YFA0901900 to J.Z).
