阿司匹林联合阿托伐他汀对脑梗死患者血脂及颈动脉粥样硬化斑块的影响

Effect of aspirin combined with atorvastatin on blood lipid and carotid atherosclerotic plaque in patients with cerebral infarction

目的探讨阿司匹林联合阿托伐他汀对脑梗死患者血脂及颈动脉粥样硬化斑块的影响。方法前瞻性分析我院2015年7月—2019年12月期间收治的脑梗死患者107例,采用随机数字表法将其分为对照组(n=53)及观察组(n=54)。两组患者用药前均接受常规治疗,对照组接受阿司匹林药治疗,在此基础上,观察组联合阿托伐他汀治疗。比较两组疗效,治疗前及治疗1个月后血脂指标及IMT改善情况。结果观察组治疗总有效率(97.78%)高于对照组(81.82%),差异有统计学意义(Z=2.020,χ^(2)=4.491,P=0.043、0.014);观察组[TG(3.45±0.69)mmol/L、TC(5.61±0.40)mmol/L、LDL(2.89±0.19)mmol/L]低于对照组[TG(4.62±0.73)mmol/L、TC(6.14±0.35)mmol/L、LDL(3.35±0.36)mmol/L],差异有统计学意义(t=8.522、7.289、8.289,P<0.001);观察组[HDL(2.04±0.31)mmol/L]高于对照组[HDL(1.87±0.24)mmol/L],差异有统计学意义(t=3.168,P=0.002);观察组[IMT(0.73±0.20)mm]低于对照组[IMT(1.19±0.14)mm],差异有统计学意义(t=13.804,P<0.001)。结论针对脑梗死患者采用阿司匹林联合阿托伐他汀治疗可有效降低患者血脂水平及颈动脉内膜中层厚度,促进病情转归。

Objective To investigate the effect of aspirin combined with atorvastatin on blood lipid and carotid atherosclerotic plaque in patients with cerebral infarction.Methods A total of 107 patients with cerebral infarction from July 2015 to December 2019 were randomly divided into a control group(53 cases)and a trail group(54 cases).Both groups received the routine treatment before medication;the patients in the control group were treated with aspirin,while the patients in the trial group received atorvastatin on the basis of the control group.The curative effects,including the blood lipid indexes and intima-media thickness(IMT)improvement were investigated and compared between the two groups before and after the treatment for one month.Results The total effective rate in the trial group(97.78%)was higher than that in the control group(81.82%),and the difference was statistically significant(Z=2.020,χ^(2)=4.491,P=0.043,0.014).Before the treatment,the blood lipid indexes in both groups had no significant differences,and after the treatment,these indexes improved in both groups.In addition,after the treatment,the blood lipid indexes[TG(3.45±0.69)mmol/L,TC(5.61±0.40)mmol/L,LDL(2.89±0.19)mmol/L]in the trial group were lower than those in the control group[TG(4.62±0.73)mmol/L,TC(6.14±0.35)mmol/L,LDL(3.35±0.36)mmol/L],and the differences were statistically significant(t=8.522,7.289,8.289,P<0.001).In the trial group,HDL[(2.04±0.31)mmol/L]was higher than that in the control group[(1.87±0.24)mmol/L],and the difference was statistically significant(t=3.168,P=0.002).After the treatment,IMT was(0.73±0.20)mm in the trial group,which was lower than that in the control group[IMT(1.19±0.14)mm],and there was a significant difference between the two groups(t=13.804,P<0.001).Conclusion Aspirin combined with atorvastatin for the cerebral infarction patients can effectively reduce the level of blood lipid and carotid IMT,and promote the outcomes of the disease.