神经肽Y在椎间盘退变发病机制中的作用

Role of neuropeptide Y in pathogenesis of intervertebral disc degeneration

椎间盘退变是退变性脊柱疾病的关键病因和病理基础,探讨椎间盘退变的病理机制对退变性脊柱疾病的防治具有重要意义。近年来,越来越多的研究表明神经肽Y(neuropeptide Y,NPY)在椎间盘退变的病理机制中发挥重要作用。本文就NPY参与椎间盘退变发病机制的研究进展进行综述,以期为退变性脊柱疾病的防治提供新参考。

Intervertebral disc degeneration is the key etiology and pathological basis of degenerative spinal diseases.Therefore,it is of great significance to research the pathogenesis of intervertebral disc degeneration for the prevention and treatment of degenerative spinal diseases.In recent years,more and more studies have found that neuropeptide Y(NPY)plays an important role in the pathological mecha⁃nism of intervertebral disc degeneration.This article reviews the research progress of NPY involving the pathogenesis of intervertebral disc degeneration,in order to provide a new reference for the prevention and treatment of degenerative spinal diseases.