TAP与传统肿瘤标志物在不同肿瘤中的相关性

Correlation between TAP and traditional tumor markers in patients with different cancers

目的:分析肿瘤异常蛋白(TAP)水平与其他10种传统肿瘤标志物在不同类型肿瘤患者中的相关性。方法:采集肺癌、结直肠癌、食管癌、胃癌患者血液样本,采用凝集素亲和方法检测TAP,采用化学发光免疫分析法检测甲胎蛋白(AFP)、癌胚抗原(CEA)、糖类抗原50(CA50)、糖类抗原19-9(CA19-9)、糖类抗原125(CA125)、糖类抗原72-4(CA72-4)、铁蛋白(FRT)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌抗原(SCC)、细胞角蛋白19片段(CYFRA21-1)。采用Spearman分析TAP与传统肿瘤标志物之间的相关性。结果:TAP水平在4种肿瘤患者中无明显差异。肺癌患者中,TAP与CA125、CA19-9、CEA、CYFRA21-1、CA50的相关性具有统计学意义(P<0.05)。结直肠癌患者中,TAP与CA19-9、CEA、CA50、CA72-4、FRT存在显著相关性(P<0.05)。胃癌患者中,TAP与CA125及CA50的相关性具有统计学意义(P<0.05)。食管癌患者中,TAP与10种传统肿瘤标志物均无显著相关性。结论:TAP与10种传统肿瘤标志物在不同类型肿瘤中的相关性并不一致,表明不同类型肿瘤细胞产生的异常糖链糖蛋白种类不同。

Objective:To analyze the correlation between TAP and 10 types of other traditional tumor markers in patients with different tumors.Methods:Blood samples were collected from patients with lung cancer,colorectal cancer,esophageal cancer and gastric cancer.TAP was detected by using lectin affinity method.The chemiluminescence immunoassay assay were used to detect of AFP,CEA,CA50,CA19-9,CA125,CA72-4,FRT,NSE,SCC and CYFRA21-1.Spearman correlation test was used to analyze the correlation between TAP and tumor markers.Results:There was no significant difference of TAP levels among patients with the different tumors.In lung cancer patients,the correlation between TAP and CA125,CA19-9,CEA,CYFRA21-1 and CA50 was statistically significant(P<0.05).In patients with colorectal cancer,TAP was significantly correlated with CA19-9,CEA,CA50,CA72-4 and FRT(P<0.05).In gastric cancer patients,the correlation between TAP and CA125,CA50 was statistically significant(P<0.05).In patients with esophageal cancer,TAP was not significantly correlated with the other traditional tumor markers.Conclusion:The correlation between TAP and 10 traditional tumor markers in different tumor was not consistent,indicating that different tumor cells produced different types of abnormal glycoprotein.