缺氧诱导因子-1α在血管性痴呆发病机制中的研究进展

Research progress of hypoxia-inducible factor-1αin the pathogenesis of vascular dementia

血管性痴呆主要是由于脑区低灌注损伤所致的,以严重认知功能障碍为主的一组临床综合征。近年来随着分子生物学研究的快速发展,血管性痴呆病理发病机制的研究逐渐向分子水平转变。缺氧诱导因子-1α作为细胞对缺氧环境适应的重要调节因子,通过直接影响靶定位基因及其蛋白质的表达,介导细胞能量代谢及维持机体细胞功能特性等途径,参与血管性痴呆的病理变化过程。本文主要就其在血管性痴呆的发病机制中的研究进展予以综述。

Vascular dementia is mainly caused by hypoperfusion injury in the brain area.It is a group of clinical syndromes with severe cognitive dysfunction.With the rapid development of molecular biology in recent years,the pathogenesis of vascular dementia has gradually changed to a molecular level.Hypoxia-inducible factor 1α(HIF-1α),as a nuclear protein with certain transcriptional activity,can regulate its own function and directly affect the expression of target-localized genes and its proteins.It also can mediate certain cellular energy metabolism and maintain the functional characteristics of the cells.As a result,it involves in the pathological changes of vascular dementia.This article reviews the current research of HIF-1αin the pathogenesis of vascular dementia.