宫颈环形电切除术和冷刀锥切术对宫颈上皮内瘤变伴高危型人乳头瘤病毒感染的疗效观察

Clinical Observation on the Surgical Outcomes of LEEP and CKC as Treantment for CIN with HR-HPV Infection

目的对宫颈上皮内瘤变(CIN)伴高危型人乳头瘤病毒(HR-HPV)感染患者采用宫颈环形电切除术(LEEP)及冷刀锥切术(CKC)治疗的效果进行对比。方法选取泰州市第三人民医院2016年6月至2019年6月收治的86例患者,按照随机数字表法分为观察组(n=44,LEEP治疗)与对照组(n=42,CKC治疗),对两组治疗效果进行对比。结果在病灶残留率、愈合率、复发率及HPV转阴率方面对比,两组差异均无统计学意义(P>0.05);在手术时间、术中出血量方面对比,观察组均低于对照组(P<0.05)。结论在CIN伴HR-HPV感染患者治疗中,宫颈环形电切除术及冷刀锥切术均能达到较好的治疗效果,但宫颈环形电切除术手术时间较短,出血量少,更有利于患者术后恢复,值得推广应用。

Objective To compare loop electrosurgical excision of cervix(LEEP)and cold knife conization(CKC)for treating cervical intraepithelial neoplasia(CIN)with high-risk human papillomavirus(HR-HPV)infection.Methods A total of 86 patients admitted to Taizhou Third People's Hospital from June 2016 to June 2019 were randomly divided into observation group(n=44,LEEP treatment)and control group(n=42,CKC treatment),and the therapeutic effects of the two groups were compared.Results There was no significant difference in the residual rate,cure rate,recurrence rate and HPV negative conversion rate between the two groups(P>0.05);in terms of operation time and intraoperative blood loss,the observation group was lower than the control group(P<0.05).Conclusion In the treatment of CIN with HR-HPV infection,both cervical LEEP and CKC can achieve good therapeutic results,but the surgery time in cervical LEEP is shorter,the volume of bleeding is less,it is more conducive to patient recovery after surgery,it is worth promoting and applying.