盐酸氨溴索辅助治疗老年肺炎的效果分析

Effect Analysis of Ambroxol Hydrochloride in Adjuvant Treatment of Senile Pneumonia

目的研究老年肺炎患者行盐酸氨溴索辅助治疗的效果。方法选取连云港市赣榆区人民医院2018年1月至2019年12月收治的64例老年肺炎患者为研究对象,采用“双盲法”分为常规组(阿奇霉素)、科研组(常规组基础+盐酸氨溴索),每组32例。比较两组患者治疗疗效。结果用药前两组患者肺功能、炎症因子比较差异无统计学意义(P>0.05);用药后科研组与常规组比较,科研组用力肺活量(FVC)、第1s用力呼气容积(FEV1)、最大呼气中段流量(MMF)及呼气峰流速(PEF)指标更高;且科研组白介素-1β(IL-1β)、白介素-6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)指标低于常规组(P<0.05);科研组有效率96.88%高于常规组81.25%(χ2=4.010,P<0.05)。结论盐酸氨溴索辅助治疗老年肺炎能提高疗效,值得借鉴。

Objective To study the effect of ambroxol hydrochloride in the treatment of elderly patients with pneumonia.Methods Totally 64 elderly patients with pneumonia admitted to People's Hospital of Ganyu District from January 2018 to December 2019 were selected as the research objects.By double-blind method,they were divided into routine group(azithromycin)and scientific group(routine group+ambroxol hydrochloride),with 32 cases in each group.The therapeutic effect was compared between the two groups.Results There were no significant differences in lung function and inflammatory factors between the two groups before treatment(P>0.05).After medication,the indexes of forced vital capacity(FVC),forced expiratory volume(FEV1),maximum mid-expiratory flow(MMF)and peak expiratory flow rate(PEF)in the scientific group were higher than those in the routine group.The indexes of interleukin-1β(IL-1β),interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)in scientific group were lower than those in routine group(P<0.05);the effective rate of the research group 96.88%was higher than that of the scientific group 81.25%(χ2=4.010,P<0.05).Conclusion Ambroxol hydrochloride adjuvant treatment of this disease can improve the curative effect,worthy of reference.