达格列净对糖尿病肾病患者肾功能改善的临床分析

Clinical Analysis of Dapagliflozin on the Improvement of Renal Function in Patients with Diabetic Nephropathy

目的探究达格列净对糖尿病肾病患者肾功能的改善效果。方法选取无锡市惠山区第二人民医院2019年5月至2020年5月收治的60例糖尿病肾病患者,采用随机数字表法分为两组,各30例。对照组采用常规治疗,观察组行达格列净治疗,对比两组血糖水平、脂代谢情况及肾功能。结果观察组治疗16周后空腹血糖(FBG)、餐后2 h血糖(PBG)及糖化血红蛋白(HbA1c)均低于对照组(P<0.05);观察组治疗16周后甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均低于对照组(P<0.05),高密度脂蛋白胆固醇(HDL-C)高于对照组(P<0.05);观察组治疗16周后血肌酐(Scr)、24 h尿蛋白定量、血尿酸(UA)均低于对照组(P<0.05)。结论达格列净治疗糖尿病肾病患者可有效降低患者血糖水平,改善其脂代谢情况及肾功能。

Objective To explore the effect of dapagliflozin on improving renal function in patients with diabetic nephropathy.Methods A total of 60 patients with diabetic nephropathy admitted to the Second People's Hospital of Huishan District,from May 2019 to May 2020 were randomly divided into two groups with 30 patients in each group.The control group received conventional treatment,and the observation group received dapagliflozin treatment.The blood glucose level,lipid metabolism and renal function of the two groups were compared.Results After 16 weeks of treatment in the observation group,FBG,PBG and HbA1c were all lower than those in the control group(P<0.05);after 16 weeks of treatment in the observation group,TG,TC and LDL-C were lower than those in the control group(P<0.05),HDL-C was higher than the control group(P<0.05);after 16 weeks of treatment,the Scr,24 h urine protein quantitative and UA of the observation group were lower than those of the control group(P<0.05).Conclusion Dapagliflozin can effectively reduce the blood sugar level of patients with diabetic nephropathy,improve their lipid metabolism and renal function.