TACE联合消融与单纯TACE术治疗对2期原发性肝癌患者肝功能与预后的影响

Effect of TACE Combined with Ablation and TACE Alone on Liver Function and Prognosis in Patients with Stage 2 Primary Hepatocellular Carcinoma

目的:探讨经肝动脉化疗栓塞术(TACE)联合消融与单纯TACE术治疗对2期原发性肝癌患者肝功能与预后的影响效果。方法:选取笔者所在医院2019年5月-2020年5月收治的2期原发性肝癌患者108例,采用随机数字法分为对照组和研究组,每组54例,对照组应用TACE术治疗,研究组应用TACE联合消融术治疗。对两组治疗前后生活质量、肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)]及治疗效果进行比较。结果:治疗前两组QOL评分比较差异无统计学意义(P>0.05),治疗后研究组各项评分均优于对照组,差异均有统计学意义(P<0.05);治疗前两组AST水平、ALT水平比较差异无统计学意义(P>0.05),治疗后研究组各项指标均低于对照组,差异均有统计学意义(P<0.05);研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论:应用TACE联合消融术治疗2期原发性肝癌患者效果明显,有利于提高患者生活质量,改善患者肝功能水平,有利于改善预后,在临床上值得进一步应用推广。

Objective:To investigate the effect of transhepatic arterial chemoembolization(TACE)combined ablation with TACE alone on liver function and prognosis in patients with stage 2 primary liver cancer.Method:A total of 108 patients with stage 2 primary liver cancer admitted to our hospital from May 2019 to May 2020 were randomly divided into control group and study group,with 54 patients in each group.The control group was treated with TACE,while the study group was treated with TACE combined with ablation.The quality of life(QOL),liver function indexes[aspartate transaminase(AST),ALT]before and after operation and therapeutic effect were compared between the two groups.Result:Before treatment,there was no significant difference in QOL score between the two groups(P>0.05).After treatment,the scores in the study group were all better than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in AST and ALT levels between the two groups(P>0.05).After treatment,all indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion:The application of TACE combined with ablation in treatment of stage 2 primary liver cancer patients has obvious effects,which is beneficial to improve the quality of life of patients,improve the level of liver function of patients,and improve the prognosis.It is worthy of further application and promotion in clinical practice.