Elafin的功能及在肿瘤中的研究进展

The function of elafin and research progress in tumor

Elafin是一种人内源性蛋白,具有抑制弹性蛋白酶的作用。在炎症过程中,它可以抑制中性粒细胞释放的弹性蛋白酶等对机体的过度损伤。既往的文献主要研究了elafin在控制炎症反应、抵抗微生物等方面的影响。近期有研究证明elafin在肿瘤中参与相关信号通路的调控从而介导肿瘤细胞的增殖迁移并影响患者预后。在本综述中,我们分析了癌症和人elafin蛋白之间存在关系的相关证据,并讨论了elafin在肿瘤进展中的潜在作用。本文就elafin的结构、功能及在肿瘤中的作用进行综述。

Elafin is a human endogenous protein that inhibits elastase.During inflammation,it can inhibit excessive damage to the body such as elastase released by neutrophils.Previous literatures have mainly studied the effects of elafin in controlling inflammatory responses and resisting microorganisms.Recent studies have demonstrated that elafin participates in the regulation of related signaling pathways in tumors to mediate tumor cell proliferation and migration as well as affect patient prognosis.In this review,we analyze relevant evidence for the relationship between cancer and human elafin proteins and discuss the potential role of elafin in tumor progression.This article reviews the structure,function and role of elafin in tumors.