胃镜检查患者辅助应用阿芬太尼的麻醉效果

Anesthesia Effect of Adjuvant Application of Alfentanil in Gastroscopy Patients

目的:观察胃镜检查患者辅助应用阿芬太尼的麻醉效果。方法:选取本院2020年5-8月240例胃镜检查患者,按照随机数字表法分为参照组与观察组,各120例。参照组给予1.5 mg/kg丙泊酚麻醉诱导,观察组给予注射3 μg/kg阿芬太尼,1 min后给予1.5 mg/kg丙泊酚,术后两组患者体动均追加丙泊酚。观察两组麻醉诱导前、胃镜达十二指肠降部时、胃镜检查结束后血流动力学及血氧饱和度,以及两组丙泊酚用量、睫毛反射消失时间、苏醒时间、定向力恢复时间。结果:麻醉诱导前,两组平均动脉压(MAP)、心率(HR)、血氧饱和度(SpO_2)比较差异无统计学意义(P>0.05)。胃镜达十二指肠降部时、胃镜检查结束后,观察组MAP、HR、SpO_2高于参照组,差异有统计学意义(P<0.05);观察组丙泊酚用量少于参照组,睫毛反射消失时间、苏醒时间、定向力恢复时间早于参照组,差异有统计学意义(P<0.05)。结论:胃镜检查患者常规丙泊酚麻醉诱导基础上,辅助应用阿芬太尼,能够提高麻醉效果,减轻患者血流动力学、血氧饱和度波动,减少丙泊酚用量,加速麻醉诱导起效时间与苏醒时间,应用价值显著。

Objective:To observe the anesthetic effect of adjuvant application of Alfentanil in gastroscopy patients.Method:A total of 240 patients with gastroscopy in our hospital from May to August 2020 were selected and randomly divided into the control group and the observation group,120 patients in each group.The reference group was given 1.5 mg/kg Propofol anesthesia induction;the observation group was given 3 μg/kg Alfentanil,after 1 min,1.5 mg/kg Propofol was given.The patients of the two groups moved after operation and Propofol was added to all patients.The hemodynamic and oxygen saturation were observed before anesthesia induction,when gastroscopy reached the descending duodenum and after gastroscopy,and the dosage of Propofol,disappearance time of eyelash reflex,awakening time and recovery time of directional force were compared between the two groups.Result:Before anesthesia induction,there were no significant differences in the mean arterial pressure (MAP),heart rate (HR),blood oxygen saturation (SpO2) between the two groups (P>0.05).When gastroscopy reached the descending duodenum and after gastroscopy,the MAP,HR and SpO2 in the observation group were higher than those in the control group (P<0.05).The dosage of Propofol in the observation group was less than that in the control group,and the disappearance time of eyelash reflex,awakening time and recovery time of directional force in the observation group were earlier than those in the control group (P<0.05).Conclusion:On the basis of routine anesthesia induction with Propofol in gastroscopy patients,the application of Alfentanil can improve the anesthetic effect,reduce the fluctuation of hemodynamics and blood oxygen saturation,reduce the dosage of Propofol,accelerate the onset time of anesthesia induction and the awakening time,which has significant application value.