金荞麦胶囊联合沙美特罗替卡松吸入粉雾剂治疗儿童支气管哮喘临床疗效研究

Clinical Efficacy of Jinqiaomai Capsules Combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation in the Treatment of Children with Bronchial Asthma

目的探讨金荞麦胶囊联合沙美特罗替卡松吸入粉雾剂治疗儿童支气管哮喘的疗效及对炎性因子、免疫功能的影响。方法选取海南省海口市琼山区妇幼保健院2018年1月至2020年1月收治的支气管哮喘患儿60例,按随机数字表法分为对照组和观察组,各30例。两组均给予沙美特罗替卡松吸入粉雾剂治疗,观察组加用金荞麦胶囊。两组均以1个月为1个疗程,共治疗3个疗程。结果观察组患儿总有效率为90.00%,显著高于对照组的63.33%(P<0.05);治疗后,观察组患儿第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC均显著高于对照组(P<0.05);观察组患儿的血清白细胞介素4、白细胞介素6、抗肿瘤坏死因子-α水平均显著低于对照组(P<0.05);观察组患儿的免疫指标(免疫球蛋白G、免疫球蛋白M、免疫球蛋白A)水平均显著高于对照组(P<0.05);观察组和对照组不良反应发生率相当(6.67%比16.67%,P>0.05)。结论金荞麦胶囊联合沙美特罗替卡松吸入粉雾剂治疗儿童支气管哮喘疗效良好,可有效缓解临床症状,改善肺功能和免疫功能,调节血清炎性因子水平,且安全性较好。

Objective To investigate the efficacy of Jinqiaomai Capsules combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation in the treatment of children with bronchial asthma and the effect on inflammatory factors and immune function.Methods A total of 60 children with bronchial asthma admitted to the Haikou Qiongshan District Maternal and Child Health Hospital from January 2018 to January 2020 were selected and divided into the control group and the observation group according to the random number table method,30 cases in each group.The patients in the control group were treated with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation,on this basis,the patients in the observation group were treated with Jinqiaomai Capsules.Both groups were treated for three courses with one month as a course of treatment.Results The total effective rate of the observation group was 90.00%,which was significantly higher than 63.33%of the control group(P<0.05).After treatment,the forced expiratory volume in one second(FEV1),forced vital capacity(FVC),FEV1/FVC in the observation group were significantly higher than those in the control group(P<0.05).The levels of serum interleukin-4(IL-4),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in the control group(P<0.05).The levels of immune indexes[immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)]in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was similar to that in the control group(6.67%vs.16.67%,P>0.05).Conclusion Jinqiaomai Capsules combined with Salmeterol Xinafoate and Fluticasone Propionate Powder for Inhalation are effective and safe in the treatment of children with bronchial asthma can effectively relieve clinical symptoms,improve pulmonary function and immune function,and regulate the level of serum inflammatory factors.