肿瘤糖代谢机制的研究进展

Advances in tumor glucose metabolism

代谢重编程是肿瘤的主要特征,其中葡萄糖代谢异常是最突出的特征。癌细胞和正常细胞中葡萄糖代谢的主要区别在于癌细胞中的葡萄糖在有氧条件下仍优先转化为乳酸,而不是在线粒体中被氧化,这一过程称为有氧糖酵解,即“瓦博格效应”。肿瘤细胞通过改变葡萄糖转运体及相关关键酶来提高代谢能力以支持肿瘤组织大量消耗葡萄糖的需要。本文就肿瘤细胞有氧糖酵解的特征做一综述,为靶向肿瘤代谢的个体化治疗寻找有效靶点。

Energy metabolism reprogramming is the main feature of tumors,and abnormal glucose metabolism is the most prominent feature.A major difference between glucose metabolism in cancer cells and normal cells is that glucose in cancer cells is preferably converted to lactate in aerobic conditions rather than oxidized in mitochondria.This process is called aerobic glycolysis,known as the"Warburg effect".Tumor cells improve the metabolic capacity by changing glucose transporters and related key regulatory enzyme to support the need of tumor tissues to consume large amounts of glucose.This article will review the characteristics of aerobic glycolysis of tumor cells and find effective targets for individualized treatments targeting tumor metabolism.