血清IgG N-聚糖在肿瘤辅助诊断中的研究现状

Research status of serum IgG N-glycans in the assistant diagnosis of tumor

免疫球蛋白(Ig)在人体抵抗外部感染和对自身异常细胞的监控、清除中扮演重要角色,位于IgG Fc段的N-聚糖在调节IgG的炎症活性上起到了重要作用,并且IgG N-聚糖成分和分布的变化与疾病的发生发展密切相关。近年来,随着对IgG N-聚糖研究的深入,大量的研究发现IgG N-聚糖的变化与恶性肿瘤的发生发展和转归存在关联,其有望成为一种用于恶性肿瘤诊断、鉴别、疗效观察和预后判断的全新生物标志物。本文就IgG N-聚糖的生物学特性、检测方法和研究进展作一综述。

Immunoglobulin(Ig)plays an important role in fight against external infections and clearance of abnormal cells in our body.N-glycan in the Fc segment of IgG acts a pivotal part in regulating the inflammatory activity of IgG.Moreover,the changes of IgG N-glycan composition and distribution are closely related to the occurrence and progression of the disease.In recent years,with the further research on IgG N-glycan,a large number of studies have found that the change of IgG N-glycan is related to the occurrence,development and outcome of malignant tumors.It is expected to be a new biomarker for the diagnosis,differentiation,efficacy observation and prognosis estimation of malignant tumors.This paper reviews the biological characteristics,detection methods and research progress of IgG N-glycan.