新生儿呼吸窘迫综合征血清HMGB1、TGF-β1、BMP-7水平及其临床意义

Serum HMGB1,TGF-β1,and BMP-7 in neonatal respiratory distress syndrome and their clinical significance

目的:探讨新生儿呼吸窘迫综合征血清高迁移率族蛋白1(high mobi lity group box-1 protein,HMGB1)、转化生长因子β1(transforming growth factorβ1,TGF-β1)、骨形态发生蛋白-7(bone morphogenetic protein-7,BMP-7)水平变化及临床意义。方法:选择2017年1月至2018年2月十堰市太和医院接诊的45例呼吸窘迫综合征新生儿作为观察组,并选择同期十堰市太和医院45位身体健康的新生儿作为对照组,比较两组新生儿一般资料、动脉血气指标、血清HMGB1、TGF-β1、BMP-7的指标水平情况,分析血清HMGB1、TGF-β1、BMP-7指标的相关性。结果:观察组的新生儿Apgar评分、胎龄、出生体重均低于对照组,差异有统计学意义(均P<0.05);观察组动脉氧分压(arterial partial pressure of oxygen,PaO2)低于对照组,动脉二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO2)、血氧饱和度(oxygen saturation,SaO2)均高于对照组,差异均有统计学意义(均P<0.05);观察组患者血清HMGB1、TGF-β1、BMP-7均明显高于对照组,差异均有统计学意义(均P<0.05);Spearman相关分析结果显示:血清HMGB1、TGF-β1和BMP-7均呈正相关(r=0.511、0.473、0.615,P<0.05)。结论:血清HMGB1、TGF-β1、BMP-7在呼吸窘迫综合征患儿中的表达明显增高,可通过炎症刺激、氧化应激等途径加重病情。血清HMGB1、TGF-β1、BMP-7可作为改善患者病情的临床评价指标。

Objective:To explore the changes and clinical significance of serum levels of high mobility group box-1 protein(HMGB1),transforming growth factorβ1(TGF-β1),and bone morphogenetic protein-7(BMP-7)in neonatal respiratory distress syndrome.Methods:Forty-five neonates with respiratory distress syndrome received in Taihe Hospital from January 2017 to February 2018 were selected as an observation group,and 45 healthy newborns in Taihe Hospital were selected as a control group during the same period.We compared the general clinical data,arterial blood gas indexes,index levels of serum HMGB1,TGF-β1,and BMP-7 in the two groups,and analyzed the correlation among serum HMGB1,TGF-β1,and BMP-7 indexes.Results:The Apgar score,gestational age,and birth weight of the observation group were lower than those of the control group,with a statistically significant difference(P<0.05);the arterial partial pressure of oxygen(PaO2)in the observation group was lower than that in the control group,and the arterial partial pressure of carbon dioxide(PaCO2)and oxygen saturation(SaO2)were higher than those in the control group,with a statistically significant difference(P<0.05);HMGB1,TGF-β1,and BMP-7 in the observation group were significantly higher than those in the control group,with a statistically significant difference(P<0.05).Spearman correlation analysis showed that serum HMGB1,TGF-β1,and BMP-7 were all positively correlated(r=0.511,0.473,0.615,P<0.05).Conclusion:The expression of serum HMGB1,TGF-β1,and BMP-7 in children with respiratory distress syndrome was significantly increased,which could aggravate the patient’s condition through inflammatory stimulation,oxidative stress,and other ways.Serum HMGB1,TGF-β1,and BMP-7 could be used as clinical evaluation indexes for the improvement of the patient’s condition.