p63阳性的弥漫大B细胞淋巴瘤1例并文献复习

p63-positive diffuse large B-cell lymphoma:A case report and literature review

弥漫大B细胞淋巴瘤是最常见的非霍奇金淋巴瘤,p63在弥漫大B细胞淋巴瘤中可表达,因此在临床上易被误诊为p63阳性的上皮源性恶性肿瘤,尤其在淋巴结发生转移时。本研究报道1例以呼吸道症状为首发症状的弥漫大B细胞淋巴瘤患者,临床高度怀疑肺恶性肿瘤并淋巴结转移。行右腋窝淋巴结穿刺活检病理诊断,结果显示p63阳性,提示为鳞状细胞癌,而完善免疫组织化学检查后,最终诊断为弥漫大B细胞淋巴瘤。因此,认识p63阳性的弥漫大B细胞淋巴瘤很有必要,可减小临床误诊的可能性。

Diffuse large B-cell lymphoma is the most common non-Hodgkin’s lymphoma.p63 is expressed in diffuse large B-cell lymphoma,which may be misdiagnosed as a p63-positive epithelial malignant tumor,especially when lymph node metastasis occurs.The study reported a patient with diffuse large B-cell lymphoma with respiratory symptoms as the first symptom.There is a high clinical suspicion of lung malignancy and lymph node metastasis.In the pathological diagnosis of right axillary lymph node biopsy,a positive p63 suggested squamous cell carcinoma,and the final diagnosis was diffuse large B-cell lymphoma after perfect immunohistochemical examination.Therefore,it is necessary to recognize p63-positive diffuse large B-cell lymphoma,which can decrease the possibility of misdiagnosis.