血清白介素-2水平表达与卒中后抑郁相关性的Meta分析

Meta Analysis of the Correlation between Serum Interleukin-2 Expression and Post-stroke Depression

目的评价血清白介素-2(serum interleukin-2,sIL-2)水平表达与卒中后抑郁(post-stroke depression,PSD)的关系。方法计算机检索中国生物医学文献(CBM),CNKI,WANFANG,PubMed和Embase等数据库,筛选有关sIL-2与PSD关系的病例对照研究,检索时间均从建库至2020年3月。根据纳入与排除标准,最终纳入9篇文献,共898例样本量,采用Review Manager 5.3软件进行统计学分析。结果sIL-2的表达在入院次日PSD组与脑梗死恢复期组间[SMD=4.39,95%CI(3.38,5.41),P<0.00001]、入院7天PSD组与脑梗死急性期组间[SMD=-1.68,95%CI(-2.19,-1.16),P<0.00001]、入院1月时PSD组与对照组(同期脑梗死组)间[SMD=2.82,95%CI(0.99,4.66),P=0.003],以及PSD组中轻度与中度抑郁组间[SMD=1.06,95%CI(0.35,1.76),P=0.003]、中度与重度抑郁组间[SMD=0.90,95%CI(0.19,1.60),P=0.01]差异均有统计学意义。结论目前的文献证据表明,sIL-2水平可能在PSD的发病机制中起重要作用,并且随着PSD程度的加重而升高。但还需要更多设计良好的前瞻性研究来进行验证。

Objective To evaluate the relationship between serum Interleukin-2(sIL-2)expression and post-stroke depression(PSD).Methods Computer was used to search CBM,CNKI,Wanfang database,PubMed and Embase to collect case-control studies about relationship between sIL-2 expression and PSD from creating database to March 2020.According to the inclusion and exclusion criteria,9 articles were finally included,with a total sample size of 898 cases.Review Manager 5.3 software was used for statistical analysis.Results The expression of sIL-2 was observed between the PSD group on the second day of admission and the cerebral infarction convalescence group[SMD=4.39,95%CI(3.38,5.41),P<0.00001],the PSD group on the first day of admission and the acute phase of cerebral infarction[SMD=-1.68,95%CI(-2.19,-1.16),P<0.00001],and the PSD group on the first month of admission and the control group(the cerebral infarction group at the same period)[SMD=2.82,95%CI(0.99,4.66),P=0.003],the mild and moderate depression groups[SMD=1.06,95%CI(0.35,1.76),P=0.003],and moderate and severe depression groups[SMD=0.90,95%CI(0.19,1.60),P=0.01]in the PSD group had statistical significance.Conclusion Current literature evidence suggests that,the level of sIL-2 may play an important role in the pathogenesis of PSD and increase with the severity of PSD,but still need to verify by more prospective studies with large-scale samples and high quality.