改良型富血小板纤维蛋白在中厚皮片供区创面中的临床应用

Clinical application of advanced platelet-rich fibrin in donor site wounds of medium thickness skin graft

选取需中厚皮植皮的80例患者,随机分为A、B、C、D 4组。供皮区分别植入改良型富血小板纤维蛋白(A-PRF)膜(A组)、富血小板纤维蛋白(PRF)膜(B组)、重组牛碱性成纤维细胞生长因子凝胶(C组)和空白对照组(D组),4组均采用凡士林纱布覆盖加压包扎,比较4组创面愈合时间、术后疼痛、瘢痕增生的情况。3种生物材料皆可促进创面愈合,其中A-PRF的临床效果最佳。A-PRF及PRF可减轻术后疼痛和瘢痕增生,A-PRF临床效果优于PRF。A-PRF可加快中厚皮供区创面愈合,减少瘢痕增生,改善愈后形态,为临床医师选择促进中厚皮供区软组织愈合及再生的生物材料提供新的思路与方法。

80 patients who needed medium-thickness skin grafts were selected and randomly divided into 4 groups A,B,C,and D.The donor sites were implanted with advanced platelet rich fibrin(A-PRF)membrane(group A),platelet-rich fibrin(PRF)membrane(B group)and recombinant bovine basic fibroblast growth factor gel(C group)respectively.Group D was the blank control group.All groups were covered with petrolatum gauze and compression bandage.The wound healing time,postoperative pain and scar hyperplasia of the four groups were compared.All three biological materials could promote wound healing,and A-PRF had the best clinical effect.APRF and PRF could reduce postoperative pain and scar hyperplasia,and the clinical effect of A-PRF was better than that of PRF.A-PRF could speed up the healing of medium-thickness skin donor site wounds,reduce scar hyperplasia,and improve post-healing morphology.A-PRF can provide new ideas and methods for clinicians to choose biomaterials to promote the healing and regeneration of soft tissues in the medium-thickness skin donor area.