白细胞介素-18与疾病的研究

Research of Interleukin-18 and Diseases

白细胞介素-18(IL-18)是IL-1细胞因子家族的成员,最初发现IL-18是被增强的抗CD3抗体刺激的Th1细胞产生的细胞因子IFN-γ。虽然IL-1和IL-18使用相同的信号通路与不同的受体结合,但具有不同的生物学特性。IL-18可以由多种免疫细胞及非免疫细胞产生,并通过与不同类型细胞上表达的特定受体结合而展示出独特的功能,在宿主抵御感染中起着至关重要的作用,其也是一种强效的促炎性细胞因子,在多种炎症条件下都具有病理生理作用,与多种疾病的发生、发展相关联,现将与IL-18有相关性的疾病研究进展进行综述,旨在阐明IL-18参与各种疾病的作用机制及其在疾病的诊断、严重程度、活动性、预后评估中的价值,以及是否可以作为与其相关疾病临床诊断的一种生物标记物,是否可以通过阻断IL-18的产生,抵消其在疾病中的生物学效应来减缓疾病的发展,帮助疾病的治疗。

IL-18 is a member of the IL-1 cytokine family.IL-18 was originally discovered to be the cytokine IFN-γproduced by Th1 cells stimulated by enhanced anti-CD3 antibodies.Although IL-1 and IL-18 use the same signaling pathway to bind to different receptors,they have different biological properties.IL-18 can be produced by a variety of immune cells and non-immune cells,and displays unique functions by binding to specific receptors expressed on different types of cells,and plays a vital role in the host's defense against infection.It is also a potent pro-inflammatory cytokine,which has pathophysiological effects under a variety of inflammatory conditions,and is associated with the occurrence and development of a variety of diseases.The research progress of diseases related to IL-18 is now reviewed,aiming to clarify the mechanism of action of IL-18 in various diseases and its value in the diagnosis,severity,activity,prognosis of the disease,and whether can it be used as a biomarker for the clinical diagnosis of related diseases,whether it can slow down the development of the disease and help the treatment of the disease by blocking the production of IL-18 and offsetting its biological effect in the disease.