静脉注射免疫球蛋白治疗儿童心肌炎有效性的Meta分析

The therapeutic effect of intravenous immunoglobulin on pediatric myocarditis:a meta-analysis

目的:探讨静脉注射免疫球蛋白(IVIG)治疗儿童心肌炎的有效性。方法:计算机检索PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI。全面收集IVIG治疗儿童心肌炎的临床研究,用Review manager 5.0软件进行Meta分析。结果:纳入5项回顾性临床研究,共223例患者。Meta分析结果表明:IVIG可提高心肌炎患儿的左心室射血分数(LVEF)[MD=18.91%,95%CI(11.74~26.08),P<0.00001],还可降低儿童心肌炎患者的病死率和心脏移植率[OR=0.31,95%CI(0.12~0.75),P=0.01]。结论:IVIG可提高儿童心肌炎患者的左心室射血分数,降低患者的死亡率和心脏移植率。

Objective:To study the therapeutic effect of intravenous immunoglobulin(IVIG)on pediatric myocarditis.Methods:The PubMed,EMBASE,Cochrane Central Register of Controlled Trials,MEDLINE,CBM,CNKI databases were searched for studies.All eligible studies were assessing the therapeutic effect of IVIG on pediatric myocarditis.The data were analyzed by Review Manager 5.0 software.Results:Five retrospective studies reporting data on 223 patients were finally included.Pediatric myocarditis receiving IVIG revealed a statistically remarkable increase in LVEF[MD=18.91%,95%CI(11.74~26.08),P<0.00001],and a decrease in death or heart transplantation at the end of follow-up[OR=0.31,95%CI(0.12~0.75),P=0.01].Conclusion:IVIG might be beneficial to improve LVEF and decrease the rate of death or heart transplantation for pediatric myocarditis.