MIF基因启动子区-173多态性与冠状动脉粥样硬化性心脏病发病风险关系的meta分析

Association between polymorphisms in MIF promoter-173 locus and risk of coronary artery disease:a meta-analysis

目的系统性评价巨噬细胞移动抑制因子(MIF)基因启动子区-173多态性与冠状动脉粥样硬化性心脏病(CAD)发病风险之间的关系。方法计算机检索中英文数据库,收集CAD与MIF基因启动子区-173多态性的病例对照研究。依据纳入标准和排除标准提取数据。Stata16.0软件进行系统分析。结果共有10个研究被纳入meta分析。结果显示,在4种遗传模型下,MIF基因启动子区-173位点单核苷酸多态性(SNP)与CAD发病风险具有相关性(等位基因模型OR=1.39;隐性基因模型OR=1.82;显性基因模型OR=1.43;纯合子基因模型OR=1.98),且该位点SNP中携带等位基因C是CAD的危险因素。亚组分析提示对于亚洲人群及非亚洲人群,该位点的SNP均与CAD发病风险相关。结论本研究发现MIF基因启动子区-173多态性与CAD发病风险明显相关,且该位点SNP中携带等位基因C是CAD的危险因素。

Objective To systematically review the association between polymorphisms in macrophage migration inhibitory factor(MIF)promoter-173 locus and risk of coronary artery disease(CAD).Methods English and Chinese databases were searched and the case-control study about the polymorphisms in MIF promoter-173 locus and risk of CAD were gathered.Datas based on inclusion criteria and exclusion criteria were extracted.System analysis was performed by using Stata16.0 software.Results A total of 10 studies were included in the meta-analysis and the results showed that in 4 genetic models,the SNP at MIF promoter-173 locus was correlated with the risk of CAD(allele model OR=1.39;recessive model OR=1.82;dominant model,OR=1.43;homozygous model OR=1.98),SNP carrying allele C at this locus was a risk factor for CAD.Subgroup analysis suggested that for both Asian and non-Asian populations,SNP at this locus was associated with the risk of CAD.Conclusion This study suggested that the polymorphisms in MIF promoter-173 locus was significantly correlated with the risk of CAD,SNP carrying allele C at this locus is a risk factor for CAD.