自噬在皮肤光损伤中的作用

Roles of autophagy in UV-induced skin damage

由紫外线(UV)辐照诱导的皮肤损伤可以引起一系列的DNA损伤反应信号通路的激活,包括细胞周期停滞、DNA损伤修复等,如果损伤不可修复,还可引起细胞凋亡。自噬是机体维持稳态的重要生物学过程,可以清除不需要的或受损的蛋白、脂质和细胞器。近年来越来越多的研究发现自噬在皮肤光损伤过程中具有重要作用,因此笔者综述了UV调节自噬的机制,以及自噬在调节细胞对UV诱导的光损伤中的作用。

Skin damage induced by UV irradiation can cause activation of a series of DNA damage response signaling pathways,such as cell cycle arrest,DNA damage repair,ect,if the damage is irreparable,it can also cause apoptosis.Autophagy is an important biological process for the body to maintain homeostasis by removing unnecessary or damaged proteins,lipids and organelles.Recent years,increasing studies have identified an important role for autophagy in the process of skin photodamage,therefore this article reviewed the mechanisms of UV-regulated autophagy and the role of autophagy in regulating cellular responses to UV-induced photodamage.