MicroRNA与舌鳞状细胞癌相关性的研究进展

Progress of research on the correlation between MicroRNA and the tongue squamous cell carcinoma

舌鳞状细胞癌(tongue squamous cell carcinoma,TSCC)是口腔恶性肿瘤中最具侵袭性的一种,占口腔癌的50%~60%。尽管在诊断和治疗技术上有了相当大的进步,但是TSCC仍然是头颈部最致命的癌症类型之一。MicroRNAs是内源性合成的小的非编码RNA,负责mRNA表达的转录后调控。它们作为有效的致癌基因或肿瘤抑制因子参与调控了包括TSCC在内的各种疾病的发病机制及过程。在TSCC样本中进行大量的MicroRNA分析,揭示了它们对TSCC起始、发展、转移、化疗耐药、复发和预后的潜在分子机制的作用。本文就MicroRNA与TSCC的相关性研究作一综述总结。

Tongue squamous cell carcinoma(TSCC)is the most aggressive type of oral malignancy,accounting for 50 to 60 percent of oral cancers.Despite the advances in diagnostic and therapeutic techniques,TSCC remains one of the deadliest forms of head and neck cancer.MicroRNAs are small,endogenous,non-coding RNAs that are responsible for post-transcriptional regulation of mRNA expression.As effective oncogenes or tumor suppressors,they participate in the regulation of the pathogenesis and process of various diseases including TSCC.A large number of MicroRNA analyses were performed in TSCC samples,revealing their effects on the potential molecular mechanisms of TSCC initiation,development,metastasis,chemotherapy resistance,recurrence,and prognosis.This paper summarizes the correlation between MicroRNA and TSCC.