武汉地区新型冠状病毒轻、重症感染检验结果危险因素分析

Analysis of laboratory results of mild and severe infection risk factors in COVID-19 in Wuhan

目的探讨武汉地区新型冠状病毒重症感染的危险因素。方法收集武汉雷神山医院就诊的新型冠状病毒肺炎(COVID-19)轻症(轻症组,42例)、重症(重症组,35例)感染者的27项检验结果,对两组资料进行χ2检验、秩和检验及非条件Logistic回归分析。结果其中17项检验指标在轻症组和重症组的差异有统计学意义(P<0.05),低密度脂蛋白(LDL)、天门冬氨酸氨基转移酶(AST)、钾离子(K^(+))、B型尿钠肽(BNP)为重症的独立危险因素,受试者工作特征(ROC)曲线分析结果显示,LDL、AST、K^(+)、BNP 4项指标的联合诊断具有最高的灵敏度,AST、K^(+)、BNP及LDL、AST、K^(+)检测组合具有最高的特异度。结论LDL、AST、K、BNP为重症的独立危险因素,监测重症患者的心功能和LDL对预防患者死亡至关重要。

Objective To explore the risk factors of SARS-CoV-2 severe infection in Wuhan.Methods Twenty-seven test results of 42 mild and 35 severe COVID-19 patients were collected from Wuhan Leishenshan Hospital.The data of two groups were analyzed by chi square,rank sum test and unconditional Logistic regression analysis.Results The difference of 17 test results between mild group and severe group was statistically significant.LDL,AST,K^(+)and BNP were independent risk factors of severe COVID-19,the combined diagnostic ROC curve of the four indicators had the highest sensitivity and specificity.Conclusion LDL,AST,K^(+)and BNP are independent risk factors of severe COVID-19.It is very important to monitor the cardiac function and LDL of COVID-19 patients to prevent death.