氧自由基在老年人造影剂肾病中作用的研究进展

The role of the oxygen free radicals in contrast-induced nephropathy in the elderly:progress in research

随着我国老龄化进程逐渐加速,冠心病、脑梗死发病率显著升高,其影像诊断、经皮介入治疗时常用含碘造影剂,造影剂以原形从肾小球滤过,且不被肾小管吸收,但造影剂在肾脏积聚可导致急性肾损伤.肾脏是人体最重要的排泄、内分泌器官之一,造影剂肾病(CIN)的防治受到广泛关注.老年人由于各脏器功能增龄性减退,造影剂相关的肾损害发病率高、预后差.目前氧自由基在老年人造影剂肾病中的作用机制尚不明确,本文对近年来国内外关于氧自由基在老年人造影剂肾病中作用的研究进行综述.

With the acceleration of the aging process in China,the incidence rates of coronary heart disease and cerebral infarction have significantly increased.And iodine contrast agent is often used in imaging diagnosis and percutaneous intervention therapy.The contrast medium is filtered from the glomerulus in its original form and is not absorbed by renal tubules.However,the accumulation of iodine contrast medium in the kidney can lead to acute kidney injury.Kidney is one of the most important excretory and endocrine organs in human body.The prevention and treatment of contrast-induced nephropathy(CIN)have been widely concerned.The incidence rate of contrast-induced renal damage is higher and the prognosis is poorer in the elderly than in the non-elderly due to the decline of organ function in the elderly.At present,the mechanism of action for oxygen free radicals in CIN of the elderly is still unclear.This article reviews the researches on the role of oxygen free radical in CIN of the elderly studied by domestic and foreign scholars in recent years.