稀有人参皂苷Rg_(5)的高效制备方法

Efficient Method for the Preparation of Rare Ginsenoside Rg_(5)

以原人参二醇组皂苷为原料,盐酸催化下制备了人参皂苷Rg_(5),并以原料中单体皂苷的转化率及人参皂苷Rg_(5)的收率为考察指标,通过单因素试验和正交试验对其进行了工艺优化。试验结果表明,影响人参皂苷Rg_(5)收率的因素主次顺序为A(反应温度)>C(酸量)>B(反应时间);最优方案为A_(2)B_(1)C_(2),即反应温度70℃,反应时间3 h,酸量125μL,此时人参皂苷Rg_(5)的收率可以达到52.32%。方法与文献方法相比,显示出原料的处理量大、Rg_(5)的收率高,因此,非常适合大量生产。

Rare ginsenoside Rg_(5)was prepared from protopanaxadiol saponins with hydrochloric acid as catalyst.Furthermore,the process condition was optimized by single factor experiment and orthogonal experiment based on conversion rate of the monomer saponins in the raw material and the yield of ginsenoside Rg_(5).The results showed that the main order of factors influencing the yield of ginsenoside Rg_(5)were A(reaction temperature)>C(acid quantity)>B(reaction time).The optimal scheme was A_(2)B_(1)C_(2),that was,the reaction temperature was 70℃,the reaction time was 3 h,and the acid quantity was 125μL.At which time the yield of ginsenoside Rg_(5)could reach 52.32%.Compared with the literature,this method showed higher raw material concentration and higher yield of Rg_(5),so it could effectively improve the preparation efficiency and was very suitable for mass production.