变应性鼻炎患者血清25-羟维生素D水平与总免疫球蛋白E及白细胞介素-13的相关性研究

Correlation between Serum 25 Hydroxyvitamin D and Total Immunoglobulin E and Interleukin-13 in Patients with Allergic Rhinitis

目的:探讨变应性鼻炎(AR)患者血清25-羟维生素D[25(OH)D]水平与总免疫球蛋白E(TIg E)及白细胞介素-13(IL-13)的相关性。方法:收集2016年7月至2018年12月期间本院收治的AR患者93例为AR组,根据病情严重程度分为轻度组23例,中度组39例,重度组31例,同期在我院体检的健康体检者93例为对照组,采用化学发光法检测血清25(OH)D水平,采用酶联免疫吸附试验检测TIg E及IL-13水平,比较AR组与对照组、不同活动度AR患者之间血清25(OH)D、TIg E及IL-13水平,分析血清25(OH)D与TIg E及IL-13的相关性。结果:AR组患者血清25(OH)D水平低于对照组,IL-13及TIg E水平高于对照组,差异有统计学意义(P<0.05)。轻度组血清25(OH)D水平高于中度组,中度组高于重度组,差异有统计学意义(P<0.05);轻度组IL-13及TIg E水平低于中度组,中度组低于重度组,差异有统计学意义(P<0.05)。AR组血清25(OH)D与IL-13、TIg E呈负相关(P<0.05);对照组血清25(OH)D与IL-13、TIg E无显著相关性(P>0.05)。结论:AR患者血清25(OH)D水平异常降低,与TIg E及IL-13呈负相关关系,可能参与了AR的发生与发展过程。

Objective: To explore the correlation between serum 25 hydroxyvitamin D [25(OH)D] and total immunoglobulin E(TIg E) and interleukin-13(IL-13) in patients with allergic rhinitis(AR). Methods: 93 case patients in our hospital from July 2016 to December 2018 were collected as AR group, 23 cases were divided into mild group, 39 cases in moderate group and 31 cases in severe group according to the severity of the disease, 93 healthy people in the same period were as control group, serum 25(OH) d level was detected by chemiluminescence method, tige and IL-13 levels were detected by enzyme-linked immunosorbent assay, serum 25(OH) d,TIg E and IL-13 levels were compared between AR group and control group, AR patients with different activity degrees, and serum 25(OH) was analyzed The correlation of D with tige and IL-13. Results: The level of serum 25(OH) d in AR group was lower than that in control group, and the level of IL-13 and TIg E were higher than those in control group(P<0.05). Serum 25(OH) d in mild group was higher than that in moderate group, and that in moderate group was higher than that in severe group, the difference was statistically significant(P<0.05);the level of IL-13 and TIg E in mild group was lower than that in moderate group, and that in moderate group was lower than that in severe group, the difference was statistically significant(P<0.05). Serum 25(OH) d was negatively correlated with IL-13 and tige in AR group(P<0.05), but not with IL-13 and tige in control group(P<0.05). Conclusion: The level of serum 25(OH) d in patients with AR decreased abnormally, which was negatively correlated with tige and IL-13. It may be involved in the occurrence and development of AR.