丹参多酚酸盐对维持性血液透析患者残余肾功能与钙磷代谢的影响

Effects of Salvia Polyphenolate on Residual Renal Function and Calcium and Phosphorus Metabolism in Patients with Maintenance Hemodialysis

目的:探讨丹参多酚酸盐对维持性血液透析患者残余肾功能与钙磷代谢的影响。方法:2014年1月-2019年5月选择在本院肾内科就诊的终末期肾病患者72例,根据随机数字表法分为观察组与对照组各36例。所有患者都给予维持性血液透析治疗,在此基础上观察组给予丹参多酚酸盐治疗,持续3个月,记录残余肾功能与钙磷代谢变化情况。结果:治疗后观察组的总有效率为97.2%,高于对照组的83.3%(P<0.05)。两组治疗后的24 h尿量、肾小球滤过率(glomerular filtration rate,GFR)、血清转化生长因子β1(Transforming growth factorβ1,TGF-β1)和白介素-6(Interleukin-6,IL-6)低于治疗前,观察组也低于对照组(P<0.05)。两组治疗后的血钙值高于治疗前,观察组也高于对照组;两组治疗后的血磷值低于治疗前,观察组也低于对照组(P<0.05)。结论:丹参多酚酸盐在维持性血液透析患者中的应用有利于残余肾功能的恢复,调节钙磷代谢平衡,抑制炎症因子的表达,从而提高治疗效果。

Objective:To investigate the effects of salvia polyphenolate on residual renal function and calcium and phosphorus metabolism in patients with maintenance hemodialysis.Methods:From January 2014 to May 2019,72 patients with end-stage renal disease who were treated in the Department of Nephrology of our hospital were selected as the research subjects and were divided into observation group and control group of 36 patients in each groups accorded to random number table method.All patients were treated with maintenance hemodialysis,and the observation group were added given salvia polyphenolate for 3 months,and the residual renal function and calcium and phosphorus metabolism were recorded.Results:The total effective rates of the observation group after treatment were 97.2%,which were higher than 83.3%of the control group(P<0.05).The 24-hour urine volume,glomerular filtration rate(GFR),serum transforming growth factorβ1(TGF-β1),and interleukin-6(IL-6)were lower in the two groups after treatment were lower than in the before treatment,and the observation group were lower than the control group(P<0.05).After treatment,the blood calcium value of the two groups were higher than before the treatment,and the observation group were higher than that of the control group(P<0.05).Conclusion:The application of salvia polyphenolate in maintenance hemodialysis patients is beneficial to the recovery of residual renal function,regulates calcium and phosphorus metabolism balance,and inhibits the expression of inflammatory factors,thereby improving the therapeutic effect.