MEBT/MEBO在慢性难愈合创面治疗中的基础与临床研究进展

Progress of Basic and Clinical Research on MEBT/MEBO in the Treatment of Chronic Refractory Wounds

烧伤创疡再生医疗技术(MEBT/MEBO)立足中西医结合理论,秉承中医整体观念,为创面营造生理性湿润环境的同时,通过转化生长因子β1 (TGF-β1)/Smad3、细胞外信号调节激酶1/2 (ERK1/2)等多种信号通路调控血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)等多种细胞因子的表达,在糖尿病足、压疮、静脉性溃疡、神经性溃疡、痛风性溃疡等多种慢性难愈合创面的治疗中发挥了减轻创面疼痛、促进创面愈合、减少愈后瘢痕形成率及截肢率等作用,取得了良好的临床疗效。为更好地指导MEBT/MEBO的临床治疗,该研究对近年来MEBT/MEBO在慢性难愈合创面治疗中的基础与临床研究进展进行了综述。

Based on the theories of integrated traditional Chinese and Western medicine and complying with the holistic view of traditional Chinese medicine,the regenerative medical technology for burns,wounds and ulcers(MEBT/MEBO)presented significant clinical efficacies in treating multiple chronic refractory wounds including diabetic foot,pres⁃sure sores,venous ulcers,neuropathic ulcers,gouty ulcers and others,by effectively relieving wound pain,promoting wound healing,preventing scar formation after wound healing and decreasing amputation rate,etc.In addition to creating a physiologically moist environment for wounds,the technology can regulate the expression of several cytokines including vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)through such signaling pathways as trans⁃forming growth factorβ1(TGF⁃β1)/Smad3,extracellular signal⁃regulated kinase 1/2(ERK1/2),etc.For the better application of MEBT/MEBO in clinical practice,this study made a review on the progress of basic and clinical research on MEBT/MEBO in the treatment of chronic refractory wounds in recent years.