MEBT/MEBO联合脂肪源性干细胞治疗慢性难愈合创面的疗效研究

Study on the Curative Effect of MEBT/MEBO Combined with Adipose⁃derived Stem Cells in the Treatment of Chronic Refractory Wounds

目的对比分析烧伤创疡再生医疗技术(MEBT/MEBO)联合脂肪源性干细胞治疗慢性难愈合创面的疗效。方法选取2017年9月至2019年8月郑州人民医院收治的72例慢性难愈合创面患者作为研究对象,并按照随机数表法将其随机分为研究组(36例)与对照组(36例),其中研究组患者采用MEBT/MEBO联合脂肪源性干细胞治疗局部创面,对照组患者单纯采用MEBT/MEBO治疗局部创面,对比观察治疗第4、8周时两组患者的临床疗效及创面最终愈合时间。结果治疗第4周,研究组患者中创面痊愈5例、显效19例、有效10例、无效2例,明显优于对照组患者的创面痊愈1例、显效9例、有效12例、无效14例(Z=-3.832,P<0.001)。治疗第8周,研究组患者中创面痊愈26例、显效7例、有效3例,明显优于对照组患者的创面痊愈8例、显效11例、有效17例(Z=-4.463,P<0.001)。最终两组患者创面均完全愈合,其中研究组患者创面愈合时间为(39.85±22.48) d,明显短于对照组患者的创面愈合时间(67.66±31.89) d (t=4.277,P <0.001)。结论 MEBT/MEBO联合脂肪源性干细胞可有效促进慢性难愈合创面愈合,缩短创面愈合时间,提高临床治疗效果。

Objective To compare and analyze the clinical efficacy of MEBT/MEBO combined with adipose⁃derived stem cells in the treatment of chronic refractory wounds.Methods Seventy⁃two patients with chronic refractory wounds,admitted to People’s Hospital of Zhengzhou from September 2017 to August 2019,were selected as the research subjects to be divided,according to the random number table,into a study group(36 cases)and a control group(36 cases).The patients in the study group were treated with MEBT/MEBO combined with adipose⁃derived stem cells,while the patients in the control group were treated with MEBT/MEBO only.The clinical efficacy at week 4 and 8 of treatment and the final wound healing time were observed and compared between the two groups.Results At week 4 of treatment,5 cases were cured,19 cases showed markedly effective,10 cases effective and 2 cases ineffective in the study group,which was signifi⁃cantly better than that in the control group(1 case cured,9 cases markedly effective,12 cases effective and 14 cases inef⁃fective.Z=-3.832,P<0.001).At week 8 of treatment,26 cases were cured,7 cases presented markedly effective and 3 cases effective in the study group,much better than 8 cases cured,11 cases markedly effective,and 17 cases effective in the control group(Z=-4.463,P<0.001).In the end,the wounds of patients in the two groups were all healed com⁃pletely.The wound healing time in the study group was(39.85±22.48)d,which was significantly shorter than(67.66±31.89)days in the control group(t=4.277,P<0.001).Conclusion MEBT/MEBO combined with adipose⁃derived stem cells can effectively promote the healing of chronic refractory wounds and shorten the wound healing time,improving clinical curative effect.