杂芳基烷基醚、杂芳基卤化物与(氘代)醇的亲核醚化

Nucleophilic Etherification of Heteroaryl Alkyl Ethers,Heteroaryl Halides with(Deuterated)Alcohols

研究了在叔丁醇钾的作用下,杂芳基烷氧化合物、杂芳基卤化物和杂芳基硫醚与各种伯、仲、叔脂肪醇高效醚化,强调了天然产物和生物活性分子的衍生化以及不易通过其他途径获得的氘代芳基烷基醚的合成方法的实用性.

A KOt-Bu empowered transition-metal free and efficient procedure for the etherification of alkoxy heteroarenes,heteroaryl halides and heteroaryl thioethers with various primary,secondary,tertiary aliphatic alcohols has been developed.The usefulness of our method is highlighted by the derivatization of natural products and bioactive molecules,and the synthesis of deuterated heteroaryl alkyl ethers that are not easy to access via other approaches.