钯催化的1,4-环己二烯的立体选择性1,3-双芳基化反应

Palladium-Catalyzed Stereoselective 1,3-Diarylation of 1,4-Cyclohexadiene

基于金属迁移的策略,发展了钯催化的1,4-环己二烯的1,3-双芳基化反应,得到单一的非对映选择性的双芳基化的产物.此反应具有优秀的区域选择性和单一的非对映选择性.实验结果表明在钯迁移的过程中烯烃并没有从钯上解离下来.这一研究为cis-1,3-双芳基取代的环己烷类化合物的合成提供了简便的方法.

A palladium-catalyzed migratory diarylation of unconjugated cyclohexadiene is disclosed,which exihibits high 1,3-regioselectivity and exclusive cis-diastereoselectivity.The excellent selectivity suggests that the olefin does not dissocate from the palladium during chain-walking.This study provides a simple method for the synthesis of 1,3-diaryl-substituted cyclohexanes.