益生菌肠道准备联合早期肠内营养在腹腔镜直肠癌根治术患者围手术期的应用

Application of probiotics intestinal preparation combined with early enteral nutrition in perioperative period of laparoscopic rectal cancer radical proctectomy

目的研究益生菌肠道准备联合早期肠内营养在腹腔镜直肠癌根治术患者围手术期的安全性和实用性。方法回顾性分析中国医科大学附属盛京医院2018年1—6月131例择期行腹腔镜直肠癌根治术患者的临床资料,其中实行益生菌肠道准备联合早期肠内营养80例(试验组),传统法肠道准备和术后处理51例(对照组)。比较两组患者术中出血量、住院费用、首次排气时间、术后住院时间、留置导尿管时间及并发症情况。结果试验组术中出血量、住院费用、术后住院时间明显少于对照组[(166.33±15.18)ml比(226.47±16.46)ml、(42365±3921)元比(51048±4772)元和(13.32±1.03)d比(13.98±1.29)d],差异有统计学意义(P<0.01);两组首次排气时间、留置导尿管时间和并发症发生率比较差异无统计学意义(P>0.05)。结论腹腔镜直肠癌根治术患者围手术期应用益生菌肠道准备联合早期肠内营养可减少住院费用、缩短住院时间,安全可行。

Objective To study the safety and practicability of probiotics intestinal preparation combined with early enteral nutrition in perioperative period of laparoscopic rectal cancer radical proctectomy.Methods The clinical data of 131 patients who underwent selective laparoscopic rectal cancer radical proctectomy in Shengjing Hospital of China Medical University from January to June 2018 were retrospectively analyzed.Among them,80 patients received probiotics intestinal preparation combined with early enteral nutrition(experimental group),and 51 patients received traditional intestinal preparation and postoperative treatment(control group).The bleeding volume during operation,hospitalization expenses,first exhaust time,postoperative hospitalization time,indwelling catheter time and complications were compared between 2 groups.Results The bleeding volume during operation,hospitalization expenses,postoperative hospitalization time in experimental group were significantly less than those in control group:(166.33±15.18)ml vs.(226.47±16.46)ml,(42365±3921)yuan vs.(51048±4772)yuan and(13.32±1.03)d vs.(13.98±1.29)d,and there were statistical differences(P<0.01).There were no statistical difference in the first exhaust time,indwelling catheter time and incidence of complications between 2 groups(P>0.05).Conclusions The probiotics intestinal preparation combined with early enteral nutrition in perioperative period can reduce the hospitalization expenses and shorten the hospitalization time in patients undergoing laparoscopic rectal cancer radical proctectomy,which is safe and feasible.