摘要
Ⅵ型分泌系统(TypeⅥSecretion System,T6SS)是近年来研究较多的一种细菌分泌系统,广泛存在于革兰氏阴性菌中,在细菌的毒力、定殖、扩散及竞争遗传中发挥着重要的作用。本文综述了细菌T6SS的结构、调控以及生物学功能的最新研究进展,以期为基于T6SS的抗菌药物研制及细菌感染的诊断与防控提供新思路。
TypeⅥsecretion system(T6 SS)that widely exists in Gram-negative bacteria has been extensive studied in recent years.It plays important roles in the virulence,colonization,spread and competition inheritance of bacteria.This paper reviews the latest research progresses in the structure,regulation and biological function of T6 SS.Hopefully,the review could inspire the development of antibacterial drugs based on T6 SS and provide new thoughts for the diagnosis and control of bacterial infections.
作者
袁思琪
李倩
毛旭虎
YUAN Siqi;LI Qian;MAO Xuhu(Department of Clinical Microbiology and Immunology,College of Pharmacy and Medical Laboratory,Army Medical University(Third Military Medical University),Chongqing 400038,China;Institute of Modem Biopharmaceuticals,State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area,School of Life Sciences,Southwest University,Chongqing 400715,China)
出处
《微生物学通报》
CAS
CSCD
北大核心
2021年第2期620-626,共7页
Microbiology China
基金
国家自然科学基金(31970135,81971907)。
关键词
Ⅵ型分泌系统
调控
生物学功能
typeⅥsecretion system
regulation
biological function
