首荟通便胶囊治疗老年功能性便秘(虚秘证)的疗效观察

Clinical observation of Shouhui Tongbian Capsules in treatment of senile functional fonstipation(deficiency syndrome)

目的观察首荟通便胶囊治疗老年功能性便秘(虚秘证)的临床疗效。方法选择天津市人民医院2017年10月—2020年1月120例老年功能性便秘(虚秘证)患者,根据就诊顺序分为对照组和治疗组,每组各60例。对照组患者服用乳果糖口服液,15 mL/次,2次/d。治疗组患者口服首荟通便胶囊,1粒/次,3次/d。两组均治疗1个月。观察两组的临床疗效,比较两组临床症状评分和远期疗效。结果治疗后,治疗组总有效率是93.33%,显著高于对照组的80.00%(P<0.05)。治疗后,两组患者便秘症状均有不同程度缓解,两组患者治疗后症状积分、Wexner评分均显著降低(P<0.05);治疗后,治疗组症状积分、Wexner评分均显著低于对照组(P<0.05)。随访发现,对照组复发率是30.0%;治疗组复发率是11.67%,治疗组显著低于对照组(P<0.05)。结论首荟通便胶囊对老年功能性便秘虚秘证的治疗效果显著,远期效果更佳,应广泛应用于临床。

Objective To investigate the clinical efficacy of Shouhui Tongbian Capsules in treatment of senile functional fonstipation(deficiency syndrome). Methods A total of 120 elderly patients with functional fonstipation(deficiency syndrome) in Tianjin People’s Hospital from October 2017 to January 2020 were selected and divided into control group and treatment group according to the order of treatment, with 60 cases in each group. Patients in the control group were po administered with Lactulose Oral Solution, 15 mL/time, twice daily. Patients in the treatment group were po administered with Shouhui Tongbian Capsules, 1 capsule/time, three times daily. Both groups were treated for 1 month. The clinical efficacy of the two groups was observed, and the clinical symptom score and long-term efficacy of the two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group(80.00%, P < 0.05). After treatment, constipation symptoms in two groups were relieved to varying degrees, and symptom score, and Wexner score in two groups were significantly decreased(P < 0.05). After treatment, symptom score and Wexner score in the treatment group were significantly lower than those in the control group(P < 0.05). Follow-up showed that the recurrence rate in the control group was 30.0%. The recurrence rate of the treatment group was 11.67%, and the treatment group was significantly lower than the control group(P < 0.05). Conclusion Shouhui Tongbian Capsules has a significant effect in treatment of senile functional constipation and its long-term effect is better, which should be widely used in clinical practice.