一清胶囊联合重组牛碱性成纤维细胞生长因子凝胶治疗复发性口腔溃疡的临床研究

Clinical study on Yiqing Capsules combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in treatment of recurrent oral ulcer

目的探讨一清胶囊联合重组牛碱性成纤维细胞生长因子凝胶治疗复发性口腔溃疡的临床疗效。方法选取2019年6月—2020年2月郑州市口腔医院收治的复发性口腔溃疡132例,随机分为对照组和治疗组,每组各66例。对照组患者局部涂擦重组牛碱性成纤维细胞生长因子凝胶,3次/d。治疗组患者在对照组基础上口服一清胶囊,2粒/次,3次/d。两组患者均治疗1周。观察两组患者临床疗效,同时比较治疗前后两组患者溃面愈合和溃疡疼痛持续时间,炎性因子白细胞介素-12(IL-12)、IL-17和肿瘤坏死因子-α(TNF-α)水平,及链球菌、韦荣氏菌和奈瑟氏菌数量水平。结果治疗后,对照组临床有效率为81.82%,显著低于治疗组的93.94%,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组溃面愈合时间、溃疡疼痛持续时间明显低于对照组(P<0.05)。治疗后,两组患者IL-12水平均显著升高,IL-17、TNF-α水平显著下降(P<0.05),且治疗组上述指标改善幅度更明显(P<0.05)。治疗后,两组链球菌、韦荣氏菌、奈瑟氏菌数量均显著升高(P<0.05),且治疗组升高更明显(P<0.05)。结论一清胶囊联合重组牛碱性成纤维细胞生长因子凝胶可显著促进复发性口腔溃疡恢复,减轻患者疼痛,纠正口腔微生态环境紊乱,临床疗效较好,且安全性较高。

Objective To investigate the clinical effects of Yiqing Capsules combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in treatment of recurrent oral ulcer. Methods Patients(132 cases) with recurrent oral ulcer in Zhengzhou Stomatological Hospital from June 2019 to February 2020 were randomly divided into control and treatment groups, and each group had 66 cases. Patients in the control group were local smear administered with Recombinant Bovine Basic Fibroblast Growth Factor Gel, three times daily. Patients in the treatment group were po administered with Yiqing Capsules on the basis of the control group, 2 grains/time, three times daily. Patients in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the ulcer healing time and ulcer pain duration, the serum inflammatory factors of IL-12, IL-17, and TNF-α, the quantities of Streptococcus, rongella and Neisseria in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.82%, which was significantly lower than 93.94% in the treatment group, and there were differences between two groups(P < 0.05). After treatment, the ulcer healing time and ulcer pain duration in the treatment group was significantly lower than that in the control group(P < 0.05). After treatment, the IL-12 levels in two groups were significantly increased, but the IL-17 and TNF-α levels were significantly decreased(P < 0.05), and the improvement of these indexes in the treatment group were significantly better than those in the control group(P < 0.05). After treatment, the quantities of Streptococcus, Rongella and Neisseria in two groups were significantly increased(P < 0.05), and which in the treatment group were significantly higher than those in the control group(P < 0.05). Conclusion Yiqing Capsules combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel can significantly promote the recovery of patients with recurrent oral ulcer, relieve the pain, and correct the disorder of oral microecological environment, which has better clinical efficacy and higher safety.