广州市境外输入性基孔肯雅热病例的流行病学和病原学特征分析

Epidemiological and etiological characteristics of imported Chikungunya fever cases,Guangzhou

目的了解2017—2019年广州市输入性基孔肯雅热(CHIKF)病例流行特征和基孔肯雅病毒(CHIKV)E1基因特征,为疫情防治工作提供科学依据。方法使用SPSS 19.0软件,采用描述性流行病学方法分析2017—2019年广州市输入性CHIKF病例流行特征,并以CHIKV的E1基因序列进行同源分析和构建系统发育树。结果广州市输入性CHIKF病例报告40例,其中经广州市中转病例15例(37.50%,15/40),归属广州市处置病例25例(62.50%,25/40)。报告时间主要分布于5—10月,占全部病例的85.00%(34/40)。所有病例中,男性34例,女性6例;年龄分布为14~68岁,中位数为33.5岁;主要为商务、经商相关人士,占52.50%(21/40)。病例输入来源国主要为亚洲国家(90.00%,36/40),其余病例均来自非洲(10.00%,4/40)。CHIKV分离株基因核苷酸和氨基酸序列同源性分别为97.34%~100.00%和93.82%~100.00%。结论5株广州市输入性CHIKV分离株属于亚洲基因型,应继续加强联防联控机制,重视开展早期诊断并采取正确防控措施。

Objective To understand the epidemiological characteristics and genetic characteristics of imported Chikungunya fever cases in Guangzhou from 2017 to 2019 and provide scientific basis for the disease prevention and control.Methods Descriptive epidemiological method was used to analyze the epidemiologic characteristics of imported Chikungunya cases in Guangzhou from 2017 to 2019 with software SPSS 19.0 software.The homology analysis and phylogenetic tree construction of E1 gene sequence of the isolated Chikungunya virus strains were carried out.Results From2017 to 2019,a total of 40 imported Chikungunya fever cases were reported in Guangzhou,in which 15(37.50%)were transferred to other areas,and 25(62.50%)were left for treatment in Guangzhou.The cases were mainly reported from May to October,accounting for 85.00%(34/40).Of all the cases,there were 34 males and 6 females,and the age ranged from 14 years to 68 years,the median of age was 33.5 years.The cases were mainly business related people,accounting for 52.50%(21/40).Most cases were from Asian countries(90.00%,36/40),and the remaining were from Africa(10.00%,4/40).From 2017 to2019,the nucleotide and amino acid sequence homologies of E1 gene of the virus strains isolated from cases were97.34%–100.00%and 93.82%–100.00%,respectively.Conclusion The five imported Chikungunya virus strains isolated in Guangzhou belonged to Asian genotype.It is necessary to further strengthen the mechanism of joint prevention and control and pay attention to early diagnosis and take correct prevention and control measures.