蜈蚣中1个喹啉类新化合物

A new quinoline alkaloid from Scolopendra subspinipes mutilans

综合运用硅胶正相色谱、反相中低压制备色谱、高压半制备液相色谱等分离和纯化方法,从蜈蚣乙酸乙酯部位中分离得到3个化合物,分别为蜈蚣素丙(1)、尿嘧啶(2)、次黄嘌呤(3),应用NMR,MS等波谱方法,并结合文献,鉴定了其化学结构,其中化合物1为喹啉类新化合物。

Three compounds,including scolosprine C(1),uracil(2)and hypoxanthine(3),were isolated and purified from the ethyl acetate fraction of centipede by silica gel normal-phase column chromatography,reversed-phase medium pressure preparation chromatography,and high-pressure semi-preparative HPLC.The structure was elucidated through a combination of spectroscopic analyses[such as nuclear magnetic resonance(NMR)and mass spectrometry(MS)]and literature review.Among them,compound 1 was a new quinoline alkaloid.In previous reports,we have described the isolation and structure elucidation of one new and two known quinoline alkaloids.In this paper,we would report the isolation and structure elucidation of scolosprine C in detail.