人乳头瘤病毒疫苗的研究进展

Research progress on human papillomavirus vaccines

人乳头瘤病毒(human papillomavirus,HPV)广泛感染人类,能够导致宫颈癌等恶性肿瘤的发生,严重危害人类的健康.HPV疫苗能够有效阻止HPV感染及其导致的疾病,世界卫生组织正在实施全球消除宫颈癌的计划.本文结合厦门大学在HPV疫苗研发中取得的研究成果,综述了HPV及其疫苗研究领域的进展,包括HPV的生物学和流行病学特征、预防性疫苗的研究现状和应用、基于结构的新一代多价疫苗设计和治疗性疫苗的研究进展等,阐述我国HPV疫苗研发从跟跑、并跑到领跑的研究历程,并展望未来HPV疫苗研究的主要方向.

Human papillomavirus(HPV)widely infects human beings,which is tightly associated with the onset of genital warts,cervical cancer,and other malignant tumors,thus poses a tremendous threat to the public health.Prophylactic vaccines have been approved as the most effective countermeasure against infectious diseases in the human history.The World Health Organization now issues a global plan aiming to eliminate the cervical cancer all over the world.This review highlights the achievement in the development of HPV vaccine obtained by Xiamen University,and outlines the progress on HPV and vaccine research,including HPV biology and epidemiology,the development and application of preventive vaccines,and rational design of next-generation vaccines,and preliminary information of therapeutic vaccines.An odyssey of HPV vaccine research and development demonstrated the efforts made by Chinese scientific community from following to keeping pace with,and then taking lead in the HPV field in the world.The trek toward the successful HPV vaccine offers an example for the innovative research in China.The main trend in the HPV vaccine research is prospected as well.