Gardner综合征的综合诊断

Comprehensive Diagnosis of Gardner Syndrome

目的探讨Gardner综合征的临床表现、影像学表现和病理学诊断方法。资料与方法回顾性分析7例Gardner综合征患者的病变部位、家族史、影像学表现及病理表现。结果7例患者中,浅表肿物5例,深部肿物3例;肠道多发性息肉7例,其中癌变或重度异形增生4例;阻生牙3例;颅面部骨瘤3例。4例有家族史。7例肠镜下均可见肠道多发性息肉,4例伴有部分癌变,CT及MRI均可见肠道外肿物,病理学检查可见大量纤维细胞增生。结论Gardner综合征临床表现多样,容易漏诊,多种技术的综合应用有助于本病的早期诊断和检出。

Purpose To explore the clinical manifestations,imaging manifestations and pathological diagnosis of Gardner syndrome.Materials and Methods The lesion location,family history,imaging findings and pathological manifestations of 7 patients with Gardner syndrome were retrospectively analyzed.Results For seven patients,there were five superficial tumors and three deep tumors;seven cases of multiple intestinal polyps,including four cases of cancerous or severe dysplasia;three cases of impacted teeth;three cases of craniofacial osteoma.Four cases had family history.Seven cases of colonoscopy showed multiple intestinal polyps,four cases were accompanied by partial cancer,CT and MRI showed extraintestinal masses,pathological examination showed a large number of fibrocytosis.Conclusion The clinical manifestations of Gardner syndrome are diverse,and it is easy to be missed.The comprehensive application of multiple techniques is helpful for the early diagnosis and detection of this disease.