艾司西酞普兰与文拉法辛治疗老年焦虑症的疗效及安全性比较

Comparison of the efficacy and safety between escitalopram and venlafaxine in the treatment of senile anxiety

目的探讨艾司西酞普兰和文拉法辛治疗老年焦虑症的疗效及安全性。方法选择2018年1月至2019年12月在我院诊断治疗的老年焦虑症患者100例为研究对象,随机分为艾司西酞普兰组与文拉法辛组,每组各50例。艾司西酞普兰组给予草酸艾司西酞普兰片口服治疗,文拉法辛组给予文拉法辛缓释片治疗。比较两组治疗后HAMA评分,临床疗效以及不良反应情况。结果(1)两组治疗后HAMA评分较治疗前均呈显著下降趋势,差异有统计学意义(P<0.05);治疗后1周、2周艾司西酞普兰组HAMA评分显著低于文拉法辛组,差异有统计学意义(P<0.05);治疗4周,两组HAMA评分比较,差异无统计学意义(P>0.05)。(2)两组临床疗效比较,差异无统计学意义(P>0.05)。(3)两组均未出现严重不良反应情况,均顺利完成疗程。艾司西酞普兰组不良反应总发生率显著低于文拉法辛组,差异有统计学意义(P<0.05)。结论与文拉法辛相比,艾司西酞普兰治疗老年焦虑症起效更快,且不良反应更少。

Objective To explore the efficacy and safety between escitalopram and venlafaxine in the treatment of senile anxiety.Methods A total of 100 elderly patients with anxiety who were diagnosed and treated in the hospital from January 2018 to December 2019 were selected as the research objects,and they were randomly divided into escitalopram group and venlafaxine group with 50 cases in each group.The escitalopram group was given oral escitalopram oxalate tablets,and the venlafaxine group was given venlafaxine sustained-release tablets.The HAMA score,clinical efficacy and adverse reactions were compared between the two groups after treatment.Results(1)The HAMA scores of the two groups showed a significant downward trend after treatment,and the difference was statistically significant compared with that before treatment(P<0.05).HAMA scores of the escitalopram group were significantly lower than those of the venlafaxine group at 1 and 2 weeks after treatment,and the difference was statistically significant(P<0.05).After 4 weeks of treatment,there was no significant difference in the HAMA score between the two groups(P>0.05).(2)There was no significant difference in clinical efficacy between the two groups(P>0.05).(3)No serious adverse reactions occurred between the two groups,and the course of treatment was successfully completed.The total incidence of adverse reactions in the escitalopram group was significantly lower than that in the venlafaxine group,and the difference was statistically significant(P<0.05).Conclusion Compared with venlafaxine,escitalopram is more effective in the treatment of senile anxiety and has fewer adverse reactions.