槐耳颗粒联合索拉非尼对晚期肝癌患者免疫功能及生活质量的影响

Effect of Huaier granule combined with sorafenib on immune function and quality of life in patients with advanced liver cancer

目的探究槐耳颗粒联合索拉非尼对晚期肝癌患者免疫功能及生活质量的影响。方法将80例晚期肝癌患者按治疗方法不同分为对照组和观察组,每组40例。对照组予以甲苯磺酸索拉非尼片口服(每次0.4 g),观察组在对照组用药基础上加用槐耳颗粒口服(每次20 g)。比较两组患者治疗总有效率、免疫功能指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、自然杀伤(NK)细胞]水平、不良反应发生率及肝胆肿瘤治疗功能评定量表(FACT-hep)评分差异。结果观察组患者总有效率为92.50%(37/40),高于对照组的72.50%(29/40),差异有统计学意义(P﹤0.05)。治疗后,两组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平均升高,CD8^(+)水平均降低,差异均有统计学意义(P﹤0.05);治疗后,观察组患者CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、NK细胞水平均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P﹤0.05)。观察组患者不良反应总发生率为17.50%(7/40),低于对照组的40.00%(16/40),差异有统计学意义(P﹤0.05)。治疗后,两组患者FACT-hep量表生理、心理、社会、功能及症状领域评分均较治疗前升高,且观察组患者生理、心理、社会、功能及症状领域评分均高于对照组,差异均有统计学意义(P﹤0.05)。结论槐耳颗粒联合索拉非尼可显著提高晚期肝癌临床疗效,改善患者免疫功能,降低不良反应发生率,提升患者生活质量。

Objective To explore the effect of Huaier granule combined with sorafenib on immune function and quality of life of patients with advanced liver cancer.Method A total of 80 patients with advanced liver cancer were divided into control group and observation group according to different treatment methods,with 40 cases in each group.The control group was given sorafenib toluenesulfonate tablets orally(0.4 g each time),while the observation group was given Huaier granules orally(20 g each time)on the basis of the control group.The total effective rate of treatment,the levels of immune function indexes[CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),natural killer(NK)cells],the incidence of adverse reactions and the functional assessment of cancer therapy-hepatobiliary(FACT-hep)score were compared between the two groups.Result The total effective rate of the observation group was 92.50%(37/40),which was higher than that of the control group(72.50%,29/40),and the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells in both groups increased,while the level of CD8^(+)decreased,the differences were statistically significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+),CD4^(+)/CD8^(+)and NK cells in the observation group were higher than those in the control group,and the level of CD8^(+) was lower than that in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 17.50%(7/40),which was lower than that in the control group(40.00%,16/40),and the difference was statistically significant(P<0.05).After treatment,the scores of CD3^(+) physiological,psychological,social,functional and symptomatic areas of the FACT-hep scale in the two groups were higher than those before treatment,and the scores of the patients in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Huaier granule combined with sorafenib can significantly improve the clinical efficacy of advanced liver cancer,improve the immune function of patients,reduce the incidence of adverse reactions and improve the quality of life of patients.