孟鲁司特联合糠酸氟替卡松对支气管哮喘患儿的效果

Effect of montelukast combined with fluticasone furoate in children with bronchial asthma

目的研究孟鲁司特联合糠酸氟替卡松对支气管哮喘患儿血清微小核糖核酸-21(miRNA-21)、微小核糖核酸-26a(miRNA-26a)相对表达量的影响以及肺功能、气道重塑情况等指标的影响。方法对照组患儿通过常规方法治疗支气管哮喘,试验组患儿在对照组治疗的基础上应用孟鲁司特联合糠酸氟替卡松进行治疗,连续治疗12周后,观察患儿的治疗效果、miRNA-21及miRNA-26a水平、气道重塑指标以及不良反应发生率。结果试验组患儿经治疗后症状改善以及肺功能恢复情况、炎症因子等各指标下降程度明显优于对照组,差异有统计学意义(P<0.05)。试验组患儿治疗后miRNA-21、miRNA-26a相对表达量、网状基底膜厚度以及成纤维细胞数量下降程度显著高于对照组患儿(P<0.05)。2组患儿的不良反应发生率比较差异无统计学意义(P>0.05)。结论孟鲁司特联合糠酸氟替卡松治疗支气管哮喘患儿能有效降低患儿血清miRNA-26a和miRNA-21的相对表达量,避免气道重塑的发生,同时能较好地抑制哮喘症状。

Objective To study the effect of montelukast combined with fluticasone furoate on the relative expression of micronucleic acid-21(miRNA-21)and micronucleic acid-26a(miRNA-26a),and the change of lung function and airway remodeling in children with asthma.Methods Children in the control group were treated by conventional methods,while the children in the experimental group were treated by montelukast combined with fluticasone furoate on the conventional basis.12 weeks after treatment,the treatment effect of children,serum miRNA-21 and miRNA-26a level,airway remodeling index and incidence of adverse reactions were observed.Results After treatment,the symptoms of children in the experimental group were improved,lung function recove-ry,inflammatory factors and other indicators decreased significantly,better than those in the control group,and the difference was statistically significant(P<0.05).The relative expression levels of miRNA-21 and miRNA-26a,the thickness of reticular basement membrane and the number of fibroblasts in the experimental group were significantly higher than those in the control group after treatment(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion The combination of montelukast and fluticasone furoate in the treatment of children with bronchial asthma can effectively reduce the relative expression levels of serum miRNA-26a and miRNA-21 in children with bronchial asthma,avoid the occurrence of airway remodeling,and well inhibit the symptoms of asthma,which has the significance of practical promotion.