摘要
MiRNA-145在大多数消化系统恶性肿瘤中下调,普遍认为其是一种肿瘤抑制因子,可以通过作用于多种细胞因子、靶向多条通路中的各种基因从而抑制不同肿瘤细胞的生长,显著降低肿瘤细胞的扩散能力,提高肿瘤细胞对化疗药物的敏感性,进而发挥其抗肿瘤作用。就miRNA-145在消化系统恶性肿瘤中的表达及其作用进行综述。
MiRNA-145 is down-regulated in most malignant tumors of the digestive system and is widely considered as a tumor suppressor that can inhibit the growth of different tumor cells by acting on various cytokines and targeting various genes in multiple pathways,it can significantly reduce the proliferation of tumor cells,improve the sensitivity of tumor cells to chemotherapeutic drugs,and then exert its anti-tumor effect.In this paper,the expression and role of miRNA-145 in malignant tumors of digestive system were reviewed.
作者
陈紫红
刘红
刘明伟
舒密
南琼
CHEN Zi-hong;LIU Hong;LIU Ming-wei;SHU Mi;NAN Qiong(Dept.of Gastroenterology,The lsZ Affiliated Hospital ofKunming Medical University,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2021年第3期145-148,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81960350)
云南省高层次卫生技术人才(学科带头人)项目(D-2018023)。
