肥厚型心肌病病理机制的研究进展

Progress in pathological mechanism of hypertrophic cardiomyopathy

肥厚型心肌病(HCM)是一种以心室非继发性非对称性肥厚为特点的心肌病,绝大部分表现为常染色体显性遗传,是年轻运动员粹死的最主要原因。近年来HCM在流行病学、致病分子机制等方面倍受关注。本文就HCM的流行病学、发病机制及其临床表现进行综述。

Hypertrophic cardiomyopathy(HCM)is a cardiomyopathy characterized by non-secondary asymmetric hypertrophy of the ventricle,most of which manifests as autosomal dominant inheritance,and it is the main cause of sudden death in young athletes.In recent years,HCM has attracted much attention in epidemiology and molecular mechanism of pathogenicity.This article reviews the epidemiology,pathogenesis and clinical manifestations of HCM.