近红外荧光显影技术在口腔癌诊疗中的应用进展

Progress in application of near-infrared fluorescence imaging in the diagnosis and treatment of oral cancer

目前,口腔癌的初步筛查多依赖于临床医生的经验,而术中原发灶切缘的确定多以体格检查及术前影像学检查为参考,缺乏术中实时且客观的评估方法。吲哚菁绿(indocyanine green,ICG)作为一种安全且无污染的有机荧光染料,可结合近红外荧光显影技术应用于早期口腔癌的筛查、肿瘤切缘的确定、前哨淋巴结的活体组织检查、颈部淋巴结的清扫以及靶向化学药物治疗等多方面。近红外荧光显影技术未来或许会成为口腔癌的早期诊断和精准治疗中关键的一环,值得深入研究。

The preliminary screening of oral cancer mostly depends on the experience of clinicians,The surgical margin of tumor is mostly based on physical examination and preoperative imaging examination.It lacks real-time and objective intraoperative evaluation methods.Indocyanine green(ICG),as a safe and pollution-free organic fluorescent pigments,combined with near-infrared fluorescence imaging can be applied in the screening of early oral cancer,the determination of tumor resection margins,sentinel lymph node biopsy,cervical lymph node dissection,targeted chemotherapy,and other aspects.Near-infrared fluorescence imaging may become a key link in the early diagnosis and accurate treatment for oral cancer in the future.