糖皮质激素联合聚桂醇治疗增生期体表草莓状毛细血管瘤的疗效及对Bcl-2、Bax mRNA的影响

Efficacy of Glucocorticoid Combined with Lauromacrogol in the Treatment of Strawberry Capillary Hemangioma in Hyperplastic Phase and Its Effects on Bcl-2 and Bax mRNA

目的:探讨糖皮质激素联合聚桂醇治疗增生期体表草莓状毛细血管瘤患者的临床疗效及对组织Bcl-2、Bax mRNA的影响。方法:选取我院2015年5月至2017年10月收治的120例增生期体表草莓状毛细血管瘤患儿120例,依据随机数表法分为观察组和对照组各60例。对照组接受常规糖皮质激素治疗,观察组给予聚桂醇+糖皮质激素治疗,比较两组患儿治疗后的疗效和不良反应发生情况,治疗前后组织Bcl-2、Bax mRNA表达量及血清血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(b FGF)表达水平。结果:观察组治疗总有效率88.33%,高于对照组的73.33%(P<0.05)。治疗后两组患儿血清VEGF、b FGF均下降,观察组低于对照组(P<0.05);Bcl-2 mRNA表达下降,Bax mRNA表达上升,其中观察组Bcl-2 mRNA低于对照组,Bax mRNA表达高于对照组(P<0.05)。两组患儿不良反应主要为局部肿胀、局部溃疡、色素沉着、向心性肥胖、高血压,发生率差异无统计学意义(P>0.05)。结论:糖皮质激素联合聚桂醇治疗增生期体表草莓状毛细血管瘤患儿的临床疗效显著,可有效降低组织Bcl-2 mRNA表达,促进Bax mRNA表达,从而加速血管瘤细胞的凋亡,提高疗效。

Objective:To probe into the clinical efficacy of glucocorticoid combined with lauromacrogol in the treatment of strawberry capillary hemangioma in hyperplastic phase and its effects on Bcl-2 and Bax mRNA.Methods:Totally 120 children with strawberry capillary hemangioma in hyperplastic phase admitted into our hospital from May 2015 to Oct.2017 were extracted to be divided into the observation group and the control group via the random number table,with 60 cases in each group.The control group was treated with conventional glucocorticoid,while the observation group received lauromacrogol combined with glucocorticoid.The efficacy and adverse drug reactions,expression of Bcl-2 and Bax mRNA,serum vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(b FGF)before and after treatment of two groups were compared.Results:The total effective rate in the observation group was 88.33%,higher than that in the control group 73.33%,the difference was statistically significant(P<0.05).After treatment,serum VEGF and b FGF decreased in both groups,and the observation group was significantly lower than the control group(P<0.05).The expression of Bcl-2 mRNA decreased,and the expression of Bax mRNA increased.The expression of Bcl-2 mRNA in the observation group was lower than that in the control group,and the expression of Bax mRNA was higher than that in the control group(P<0.05).Adverse drug reactions were mainly local swelling,local ulcers,pigmentation,central obesity,and hypertension,and there was no statistically significant difference(P>0.05).Conclusion:The clinical efficacy of glucocorticoid combined with lauromacrogol in the treatment of strawberry capillary hemangioma in hyperplastic phase is significant,which can effectively reduce the expression of Bcl-2 mRNA and promote the expression of Bax mRNA,so as to accelerate the apoptosis of hemangioma cells and improve the efficacy.