视网膜激光光凝联合康柏西普玻璃体腔注射治疗视网膜分支静脉阻塞继发黄斑水肿的疗效研究

Study on the Efficacy of Retinal Laser Photocoagulation Combined with Intravitreal Injection of Conbercept in the Treatment of Macular Edema Secondary to Branch Retinal Vein Occlusion

目的:探究视网膜激光光凝联合康柏西普玻璃体腔注射治疗视网膜分支静脉阻塞(BRVO)继发黄斑水肿的疗效。方法:选取2018年1月~2020年1月在本院接受治疗的86例BRVO继发黄斑水肿的患者作为研究对象,采用随机数字表法将患者分为观察组和对照组,各43例。观察组予以视网膜激光光凝联合康柏西普玻璃体腔注射治疗,对照组予以康柏西普玻璃体腔注射治疗。比较两组治疗前和治疗后最佳矫正视力(BCVA)、视力提高率、黄斑中心凹厚度(CMT)、眼内压变化情况及并发症发生率。结果:治疗1、3、6个月后两组患者BCVA值、CMT值、眼内压均低于治疗前(P> 0.05);且治疗3、6个月后观察组BCVA值、CMT值、眼内压均低于对照组(P <0.05)。观察组患者视力提高率高于对照组(P <0.05)。两组患者治疗期间不良反应发生率均较低,无统计学差异(P>0.05)。结论:视网膜激光光凝联合康柏西普玻璃体腔注射治疗能够改善BRVO继发黄斑水肿病情,提高患者视力,且安全性较高。

Objective:To explore the efficacy of retinal laser photocoagulation combined with intravitreal injection of conbercept in the treatment of macular edema secondary to branch retinal vein occlusion(BRVO).Methods:86 patients with macular edema secondary to BRVO treated in our hospital from January 2018 to January2020 were divided into observation group and control group according to the random number methods,with 43 cases in each group.The observation group was treated with retinal laser photocoagulation combined with intravitreal injection of conbercept,while the control group with intravitreal injection of conbercept alone.The best corrected visual acuity(BCVA),visual acuity improvement rate,central macular thickness(CMT),intraocular pressure and complication rate were compared between two groups before and after treatment.Results:1,3 and 6 moths after treatment,the values of BCVA,CMT and intraocular pressure in two groups were lower than those before treatment(P>0.05).And the values of BCVA,CMT and intraocular pressure in the observation group were lower than those in the control group 3 and 6 months after treatment(P<0.05).The visual acuity improvement rate in the observation group was higher than that in the control group(P<0.05).The complication rate was low in both groups,without significant difference between two groups(P>0.05).Conclution:Retinal laser photocoagulation combined with intravitreal injection of conbercept can improve the condition of macular edema secondary to BRVO and the visual acuity of patients,with high safety.