中国七省人群PPARγ2基因Pro12Ala多态性与肥胖相关性的Meta分析

Meta-analysis of the association between PPARγ2 gene Pro12Ala polymorphism and obesity in Chinese population

目的探讨中国人群过氧化物酶体增殖子激活受体γ(peroxisome proliferator-activated receptorγ,PPARγ)2基因Pro12Ala多态性与肥胖发病风险的关系。方法以"过氧化物酶体增殖子激活受体γ2"、"PPARγ2"、"pparg2"、"peroxisome proliferator-activated receptor gamma2"、"肥胖"、"Pro12Ala"、"基因多态性"、"polymorphism"、"Chinese"为检索词,检索中文数据库中国知网、万方数据库、维普科技期刊全文数据库和外文数据库PubMed、Embase、Cochrane Library、Web of Science中发表于自数据库建立至2019年12月31日的以中国人群为研究对象的文献。对文献评分≥5分的文献利用RevMan 5.3软件进行Meta分析。结果共纳入7个省(自治区)的10篇文献,其中病例1388名,对照1247名。Meta分析显示,(1)显性基因模型:携带Ala/Ala+Pro/Ala型者肥胖发生的风险是携带Pro/Pro型者的1.86倍(OR=1.86,95%CI 1.07~3.21);(2)加性基因模型:携带Pro/Ala型者肥胖发生的风险是携带Pro/Pro型者的1.79倍(OR=1.79,95%CI 1.04~3.08);(3)等位基因模型:携带等位基因Ala者肥胖发生的风险是携带等位基因Pro者的1.75倍(OR=1.75,95%CI 1.11~2.78)。对不同地区进行亚组分析,南方地区显性基因模型、加性基因模型和等位基因模型的合并OR(95%CI)值分别为1.96(1.12~3.42)、2.02(1.14~3.56)和1.79(1.06~3.03),北方地区显性基因模型、加性基因模型和等位基因模型的合并OR(95%CI)值分别为1.89(0.90~3.97)、1.77(0.85~3.67)和1.80(0.97~3.36)。结论中国人群PPARγ2基因Pro12Ala多态性等位基因Ala或基因型Ala/Ala或Pro/Ala会增加肥胖发生的风险,南方地区人群相关性更为明显。

OBJECTIVE To explore the relationship between the peroxisome proliferator-activated receptor γ(PPARγ) 2 gene Pro12 Ala polymorphism and the risk of obesity in the Chinese population. METHODS Take "peroxisome proliferator activated receptor gamma2", "PPAR gamma2", "pparg2", "peroxisome proliferator-activated receptor gamma2", "obesity", "Pro12 Ala", "gene polymorphism", "Chinese" as searchable words, Chinese people were selected as study subjects from Chinese databases such as CNKI, Wanfang Database, VIP and foreign language databases such as PubMed, Embase, Cochrane Library and Web of Science, which were published from the establishment of the database until December 31, 2019. RevMan 5.3 software was used for Meta-analysis of the literature with literature score ≥ 5 points. RESULTS A total of 12 articles were included, including 2233 cases and 1795 healthy controls. Meta-analysis showed that:(1) Dominant gene model: the risk of obesity for those carrying Ala/Ala+Pro/Ala was 1.86 times that of those carrying Pro/Pro(OR=1.86, 95%CI 1.07-3.21).(2) Additive gene model: the risk of obesity for those carrying Pro/Ala was 1.79 times that of those carrying Pro/Pro(OR=1.79, 95% CI 1.04-3.08).(3) Allelic model: the risk of obesity in those carrying the allele Ala was 1.75 times that of those carrying the allele Pro(OR=1.75, 95% CI 1.11-2.78). The subgroup analysis of different regions showed that the combined OR(95% CI) values of the dominant gene model, additive gene model and allelic model in the southern region were 1.96(1.12-3.42), 2.02(1.14-3.56) and 1.79(1.06-3.03), the combined OR(95% CI) values of the dominant gene model, additive gene model and allele model in the northern region were 1.89(0.90-3.97), 1.77(0.85-3.67) and 1.80(0.97-3.36). CONCLUSION The polymorphic allele Ala or genotype Ala/Ala or Pro/Ala of PPARγ2 gene may increase the risk of obesity in Chinese population.The correlation between the PPARγ2 gene Pro12 Ala polymorphism and the risk of obesity in the southern population is more obvious.