微生态制剂联合奥美拉唑序贯治疗幽门螺旋杆菌阳性消化性溃疡效果及对患儿丙二醛、转化生长因子β1蛋白水平和肠道菌群的影响

Effect of probiotics combined with omeprazole sequential therapy in treatment of Helicobacter pylori-positive peptic ulcer and its influence on MDA,TGF-β1 protein levels and intestinal flora in children

目的:探究微生态制剂联合奥美拉唑序贯疗法治疗幽门螺旋杆菌(HP)阳性消化性溃疡的效果及对患儿丙二醛(MDA)、转化生长因子β1(TGF-β1)蛋白水平和肠道菌群的影响。方法:纳入小儿消化性溃疡(PU)患儿120例,随机分为序贯组和微生态制剂组,各60例。序贯组使用奥美拉唑序贯疗法,微生态制剂组在序贯组的基础上间隔2 h后使用双歧杆菌四联活菌片。比较两组的疗效,MDA、TGF-β1水平,HP根除率、溃疡愈合率、复发率,肠道菌群变化以及不良反应发生率。结果:微生态制剂组的治疗有效率明显高于序贯组(P<0.05)。治疗后,微生态制剂组MDA、TGF-β1水平、复发率、不良反应发生率均明显低于序贯组(均P<0.05)。微生态制剂组HP根除率和溃疡愈合率均明显高于序贯组(均P<0.05)。治疗后,微生态制剂组双歧杆菌、肠球菌、类杆菌和定植抗力(B/E)均明显高于序贯组,肠杆菌明显低于序贯组(均P<0.05)。结论:奥美拉唑序贯疗法联合微生态制剂治疗HP阳性PU,疗效确切,能够有效减轻机体炎症反应,促进HP的根除,降低复发率,维持肠道菌群的平衡,且安全性好。

Objective:To study the effect of probiotics combined with omeprazole sequential therapy in the treatment of Helicobacter pylori(HP)-positive peptic ulcer(PU)and its influence on the level of MDA,TGF-β1 and intestinal flora in children.Methods:120 children with PU were included and randomly divided into sequential group and probiotic group,60 cases in each group.Sequential group was treatment with omeprazole sequential therapy,and probiotic group was treatment with bifidobacteria quadruple viable tablets after 2 hours on the basis of sequential group.The curative effects,the levels of MDA and TGF-β1,HP eradication rate,ulcer healing rate,recurrence rate,changes of intestinal flora and the incidence of adverse reactions were compared between the two groups.Results:The effective rate of treatment in the probiotic group was significantly higher than that in the sequential group(P<0.05).After treatment,the levels of MDA and TGF-β1,recurrence rate,and incidence of adverse reactions in the probiotic group were significantly lower than those in the sequential group(all P<0.05).The HP eradication rate and ulcer healing rate in the probiotic group were significantly higher than those in the sequential group(all P<0.05).After treatment,Bifidobacterium,Enterococcus,Bacteroides and B/E in the probiotic group were significantly higher than those in the sequential group,and Enterobacter was significantly lower than that in the sequential group(all P<0.05).Conclusion:Omeprazole sequential therapy combined with probiotics in the treatment of HP-positive PU has a definite effect.It can effectively reduce the body’s inflammatory response,promote the eradication of HP,reduce the recurrence rate,maintain the balance of intestinal flora,and has good safety.